Weekly shot aims to shed pounds and soothe aching knees

NCT ID NCT07509307

First seen Apr 07, 2026 · Last updated May 01, 2026 · Updated 2 times

Summary

This study tests a new once-weekly injection (NNC0487-0111) in 400 adults with overweight or obesity and knee osteoarthritis. Participants are randomly assigned to receive either the study drug or a placebo. The goal is to see if the drug helps with weight loss and reduces knee pain and stiffness.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • "Zdrowie Osteo-Medic" s.c. Lidia i Artur Racewicz, Agnieszka i Jerzy Supronik

    Bialystok, Podlaskie Voivodeship, 15-351, Poland

  • ALPHA Recherche Clinique

    Lévis, Quebec, G6V 0C9, Canada

  • ALPHA Recherche Clinique

    Québec, Quebec, G3K 2P8, Canada

  • Aarhus Universitetshospital - Klinik for Led og bindevævssygdomme

    Aarhus N, 8200, Denmark

  • Adana Şehir Eğitim ve Araştırma Hastanesi-Fizik Tedavi ve Rehabilitasyon

    Yuregir/Adana, 01060, Turkey (Türkiye)

  • Advanced Res for Health Improve

    Naples, Florida, 34102, United States

  • Ankara Bilkent Şehir Hastanesi- Fizik Tedavi ve Rehabilitasyon

    Çankaya/Ankara, 06800, Turkey (Türkiye)

  • Arcturus Healthcare, PLC.

    Troy, Michigan, 48098-6368, United States

  • Athens Medical Center S.A. (Iatriko Athinon) - Diabetes and Obesity Unit

    Marousi, 15125, Greece

  • Athens Medical Center S.A. (Iatriko Psychicou) - Department of Internal Medicine & Metabolic Diseases

    Athens, 11525, Greece

  • Auxologico San Luca - Endocrinologia e Malattie del Metabolismo

    Milan, Lombardy, 20149, Italy

  • Azienda Ospedaliera Universitaria Integrata Verona - Ospedale Civile Maggiore Borgo Trento - U.O. Reumatologia

    Verona, Veneto, 37126, Italy

  • Bursa Yüksek İhtisas Eğitim ve Araştırma Hastanesi-Fizik Tedavi ve Rehabilitasyon

    Yıldırım/Bursa, 16310, Turkey (Türkiye)

  • CNS Healthcare

    Jacksonville, Florida, 32256, United States

  • Casa della Salute di Ceccano - Ambulatori Campus Biomedico

    Rome, Lazio, 00128, Italy

  • CenterMed Kraków Sp. z o.o.

    Krakow, 31-530, Poland

  • Centre Medical Acadie

    Montreal, Quebec, H4N 2W2, Canada

  • Centre de Recherche du CHUS

    Sherbrooke, Quebec, J1H 5N4, Canada

  • Centro Especialidades Hermanos Sangro

    Madrid, 28038, Spain

  • Centrum Medyczne Intercor Sp. z o.o.

    Bydgoszcz, 85-605, Poland

  • Chase Medical Research LLC

    Waterbury, Connecticut, 06708, United States

  • ClinicMed Daniluk, Nowak Spółka Komandytowa

    Bialystok, 15-879, Poland

  • Clinical Investigation Spec Gurnee

    Gurnee, Illinois, 60031, United States

  • Clinvest Research

    Springfield, Missouri, 65807, United States

  • Clínica Nuevas Tecnologías en Diabetes y Endocrinología

    Seville, 41003, Spain

  • Coastal Digestive Health

    Maroochydore, Queensland, 4558, Australia

  • Desert Oasis Healthcare

    Palm Springs, California, 92262, United States

  • Emeritus Research Sydney

    Botany, New South Wales, 2019, Australia

  • Evangelismos S.A. - Endocrinology department

    Athens, 10676, Greece

  • Evanston Premier Hlthcr Res

    Skokie, Illinois, 60077, United States

  • First Valley Medical Group

    Lancaster, California, 93534, United States

  • Frederiksberg Hospital - Parker Institutet (Artrose)

    Frederiksberg, 2000, Denmark

  • H. Infanta Luisa_Endocrino y Obesidad

    Seville, 41010, Spain

  • Health Res of Hampton Roads

    Newport News, Virginia, 23606, United States

  • Heart of Australia

    Chelmer, Queensland, 4068, Australia

  • Hospital For Special Surgery

    New York, New York, 10021, United States

  • Hospital General de Valencia

    Valencia, 46014, Spain

  • Hospital Germans Trias i Pujol

    Badalona, 08916, Spain

  • Hospital HM La Esperanza

    Santiago de Compostela, 15705, Spain

  • Hospital Infanta Sofía

    San Sebastián de Los Reyes (Madrid), 28702, Spain

  • Hospital Naval Ferrol

    Ferrol, 15405, Spain

  • Hospital Quirónsalud Málaga

    Málaga, 29004, Spain

  • Hospital Universitario Marqués de Valdecilla

    Santander, 39008, Spain

  • Instituto Medico Quirurgico San Rafael

    A Coruña, 15006, Spain

  • Istanbul Üniversitesi- Istanbul Tıp Fakültesi Esnaf Hastanesi Poliklinikleri Fiziksel Tıp Ve Rehabilitasyon Anabilim Dalı

    Fatih/İstanbul, 34116, Turkey (Türkiye)

  • Kolling Institute

    St Leonards, New South Wales, 2065, Australia

  • Laiko General Hospital Of Athens - 1st department of Internal Medicine

    Athens, 115 27, Greece

  • Latin Clinical Trial Center Puerto Rico

    San Juan, 00909, Puerto Rico

  • MC Dr. Atanasov EOOD

    Sofia, 1231, Bulgaria

  • MC Excelsior OOD

    Sofia, 1407, Bulgaria

  • MMA MHAT - Sofia, Rheumatology clinic

    Sofia, 1606, Bulgaria

  • Mercy Family Clinic

    Dallas, Texas, 75208, United States

  • Momentum Clinical Research Darlinghurst

    Darlinghurst, New South Wales, 2010, Australia

  • Monroe Biomedical Research, LLC

    Louisville, Kentucky, 40213, United States

  • NYU Langone Health

    New York, New York, 10016, United States

  • Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji im. prof. dr hab. med. Eleonory Reicher

    Warsaw, 02-637, Poland

  • Neighborhood Healthcare

    Escondido, California, 92025, United States

  • NextHealth S.A. - Department of Endocrinology, Metabolism & Diabetes

    Thessaloniki, 54635, Greece

  • Northwest Clinical Research Center

    Bellevue, Washington, 98007, United States

  • Northwest Research Center

    Portland, Oregon, 97202, United States

  • Ospedale Galeazzi S.p.A. - INCO - Istituto Nazionale per la Cura dell'Obesità

    Milan, Lombardy, 20157, Italy

  • Ospedale S. Maria della Misericordia - Reparto Endocrinologia e Malattie del Metabolismo

    Udine, Friuli Venezia Giulia, 33100, Italy

  • Piedmont Healthcare/Research

    Statesville, North Carolina, 28625, United States

  • Pol. Uni. Campus Biomedico - UOC Endocrinologia e Diabetologia

    Rome, Lazio, 00128, Italy

  • Policlinico San Donato di Milano S.p.A - UOS Endocrinologia e del Servizio di Nutrizione Clinica e Prevenzione Cardiometabolica

    San Donato Milanese, Lombardy, 20097, Italy

  • SBÜ Ankara Gaziler Fizik Tedavi Ve Rehabilitasyon Eğitim Ve Araştırma Hastanesi

    Çankaya/Ankara, 06800, Turkey (Türkiye)

  • Sanos Clinic - Herlev

    Herlev, 2730, Denmark

  • Szpital Specjalistyczny im. Ludwika Rydygiera w Krakowie Sp. z o.o.

    Krakow, 31-826, Poland

  • TLC Diabetes and Endocrinology

    Surrey, British Columbia, V3T 2V6, Canada

  • Thermi Clinic S.A. - Diabetes and Internal Medicine Department

    Thessaloniki, 57001, Greece

  • Trakya Üniversitesi Tıp Fakültesi Hastanesi-Fizik Tedavi ve Rehabilitasyon

    Edirne, 22030, Turkey (Türkiye)

  • UMHAT Sveti Georgi EAD, Plovdiv

    Plovdiv, 4002, Bulgaria

  • UMHAT Sveti Ivan Rilski EAD, Rheumatology

    Sofia, 1612, Bulgaria

  • UMHAT Tsaritsa Yoanna - ISUL EAD, Orthopaedics and Traumatology

    Sofia, 1527, Bulgaria

  • University General Hospital Attikon General Hospital Of West Attica H Agia Varvara - 2nd dept of Internal medicine

    Chaïdári, Attica, 12461, Greece

  • Westside Center For Clinical Research

    Jacksonville, Florida, 32205, United States

  • Your Research Network

    Niagara Falls, Ontario, L2H 1H5, Canada

  • İstanbul Fizik Tedavi ve Rehabilitasyon Eğitim ve Araştırma Hastanesi

    Bahçelievler/İstanbul, 34186, Turkey (Türkiye)

Conditions

Explore the condition pages connected to this study.