Can more radiation save rectums? new trial aims to find out
NCT ID NCT04095299
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase 3 trial compares standard versus higher-dose radiotherapy, combined with chemotherapy, in 162 people with early low or mid rectal cancer. The goal is to see if a higher dose helps more patients achieve a complete response and avoid surgery, preserving their rectum. Participants will be monitored closely for two years to check if the cancer stays away.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Radiotherapy (standard or high dose) plus chemotherapy (capecitabine)
What this could lead to
If successful, this could offer a way for some early rectal cancer patients to avoid surgery and keep their rectum, improving quality of life.
What could go wrong
This is a phase 3 trial, but it's still uncertain if the higher dose will work better. Risks include side effects from radiation and chemotherapy, and the cancer may still come back.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Aalborg University Hospital
RECRUITINGAalborg, Denmark
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Copenhagen University Hospital, Righshospitalet and Bispebjerg Hospital
RECRUITINGCopenhagen, Denmark
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Department of Oncology, Vejle Hospital
RECRUITINGVejle, Denmark
Contact Email: •••••@•••••
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Zealand University Hospital, Næstved
RECRUITINGNæstved, Denmark
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Zealand University Hospital, Roskilde
RECRUITINGRoskilde, Denmark