New vaccine combo aims to tame chronic hepatitis b

NCT ID NCT05343481

Completed Disease control Sponsor: Barinthus Biotherapeutics Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 2b trial tested a combination of two experimental vaccines (VTP-300) plus a low dose of the cancer drug nivolumab in 121 adults with chronic hepatitis B who were already on antiviral medication. The goal was to see if the treatment could significantly lower hepatitis B surface antigen levels in the blood. The study is now complete, and researchers are evaluating safety and effectiveness.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: VTP-300 (two vaccines: ChAdOx1-HBV and MVA-HBV) plus low-dose nivolumab (Opdivo)
What this could lead to: If successful, this combination could help control chronic hepatitis B by reducing the virus's surface antigen, potentially allowing some patients to stop long-term antiviral therapy.
What could go wrong: This is a mid-stage trial with only 121 participants, so results may not apply to everyone. The treatment involves immune modulation, which can cause side effects like inflammation or autoimmune reactions.

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Conditions

The condition(s) this trial relates to.

chronic hepatitis B virus infection hepatitis B virus infection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC HEPATITIS B

Contacts and locations

Locations

Bamrasnaradura Infectious Diseases Institute

Nonthaburi, Thailand, 11000, Thailand
Chang Gung Memorial Hospital Kaohsiung

Kaohsiung City, Taiwan
Chia-Yi Christian Hospital

Chiayi City, Taiwan, 60002, Taiwan
China Medical University Hospital

Taichung, Taiwan, 404332, Taiwan
Chulabhorn Hospital

Bangkok, Thailand, 10210, Thailand
Dalin Tzu Chi Hospital

Chiayi City, Taiwan
HIV Netherlands-Australia-Thailand Research Collaboration

Bangkok, Thailand, Thailand
Hospital For Tropical Diseases

Bangkok, Thailand
Kaohsiung Medical University Chung-Ho Memorial Hospital

Kaohsiung, Taiwan, 807, Taiwan
King Chulalongkorn Memorial Hospital

Bangkok, Thailand, 10330, Thailand
Linkou Chang Gung Memorial Hospital

Taoyuan City, Taiwan, 333, Taiwan
Maharaj Nakorn Chiang Mai Hospital

Chiang Mai, Thailand, 50200, Thailand
National Cheng Kung University Hospital

Tainan, Taiwan, 704, Taiwan
National Taiwan University Hospital

Taipei, Taiwan
Prince Of Wales Hospital

Hong Kong, Hong Kong
Queen Mary Hospital

Hong Kong, Hong Kong
Research Institute For Health Sciences

Chiang Mai, Thailand
Srinagarind Hospital

Khon Kaen, Thailand

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