New vaccine combo aims to tame chronic hepatitis b
NCT ID NCT05343481
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase 2b trial tested a combination of two experimental vaccines (VTP-300) plus a low dose of the cancer drug nivolumab in 121 adults with chronic hepatitis B who were already on antiviral medication. The goal was to see if the treatment could significantly lower hepatitis B surface antigen levels in the blood. The study is now complete, and researchers are evaluating safety and effectiveness.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
VTP-300 (two vaccines: ChAdOx1-HBV and MVA-HBV) plus low-dose nivolumab (Opdivo)
What this could lead to
If successful, this combination could help control chronic hepatitis B by reducing the virus's surface antigen, potentially allowing some patients to stop long-term antiviral therapy.
What could go wrong
This is a mid-stage trial with only 121 participants, so results may not apply to everyone. The treatment involves immune modulation, which can cause side effects like inflammation or autoimmune reactions.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Bamrasnaradura Infectious Diseases Institute
Nonthaburi, Thailand, 11000, Thailand
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Chang Gung Memorial Hospital Kaohsiung
Kaohsiung City, Taiwan
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Chia-Yi Christian Hospital
Chiayi City, Taiwan, 60002, Taiwan
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China Medical University Hospital
Taichung, Taiwan, 404332, Taiwan
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Chulabhorn Hospital
Bangkok, Thailand, 10210, Thailand
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Dalin Tzu Chi Hospital
Chiayi City, Taiwan
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HIV Netherlands-Australia-Thailand Research Collaboration
Bangkok, Thailand, Thailand
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Hospital For Tropical Diseases
Bangkok, Thailand
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Kaohsiung Medical University Chung-Ho Memorial Hospital
Kaohsiung, Taiwan, 807, Taiwan
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King Chulalongkorn Memorial Hospital
Bangkok, Thailand, 10330, Thailand
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Linkou Chang Gung Memorial Hospital
Taoyuan City, Taiwan, 333, Taiwan
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Maharaj Nakorn Chiang Mai Hospital
Chiang Mai, Thailand, 50200, Thailand
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National Cheng Kung University Hospital
Tainan, Taiwan, 704, Taiwan
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National Taiwan University Hospital
Taipei, Taiwan
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Prince Of Wales Hospital
Hong Kong, Hong Kong
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Queen Mary Hospital
Hong Kong, Hong Kong
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Research Institute For Health Sciences
Chiang Mai, Thailand
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Srinagarind Hospital
Khon Kaen, Thailand