New pill aims to stop the relentless itch of a rare liver disease

NCT ID NCT05050136

Recruiting now Symptom relief Sponsor: Mirum Pharmaceuticals, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests an experimental drug called volixibat for people with primary biliary cholangitis (PBC) who suffer from severe itching. The trial will involve 260 adults and compare volixibat against a placebo to see if it safely reduces itch severity and improves quality of life. It is a Phase 2 study, meaning it is still early and results are not yet confirmed.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: volixibat
What this could lead to: If it works, this could offer a new way to relieve severe itching in people with primary biliary cholangitis, improving daily comfort and quality of life.
What could go wrong: This is an early Phase 2 trial, so results are not yet proven. The drug may not reduce itching better than placebo, and side effects are still being studied.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cholangitis Digestive System Diseases primary biliary cholangitis primary biliary cholangitis 1 Pruritus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PBC PRIMARY BILIARY CHOLANGITIS

Contacts and locations

Locations

(G.I.R.I.) GI Research Institute Foundation
RECRUITING

Vancouver, British Columbia, V6Z 2K5, Canada
ASST Grande Ospedale Metropolitano Niguarda
RECRUITING

Milan, 20162, Italy
ASST Papa Giovanni XXIII
RECRUITING

Bergamo, 24127, Italy
Advanced Research Institute, Inc
RECRUITING

New Port Richey, Florida, 34653, United States
Amel Med LLC
TERMINATED

Austin, Texas, 78750, United States
Amstedam University Medical Centers
RECRUITING

Amsterdam, 1081 HV, Netherlands
Azienda Ospedale-Università di Padova
RECRUITING

Padova, 35128, Italy
Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone
RECRUITING

Palermo, 90127, Italy
Azienda Ospedaliero Universitaria Di Modena
RECRUITING

Modena, 41126, Italy
Azienda Ospedaliero Universitaria Pisana (AOUP)
RECRUITING

Pisa, 56124, Italy
Baylor College of Medicine
RECRUITING

Houston, Texas, 77030, United States
Beijing Friendship Hospital, Capital Medical University
RECRUITING

Beijing, 10050, China
Beijing Youan Hospital, Capital Medical University
RECRUITING

Beijing, 100069, China
Belfast Health & Social Care Trust (BHSCT) Royal Victoria Hospital
RECRUITING

Belfast, BT12 6BA, United Kingdom
Beth Israel Deaconess
RECRUITING

Boston, Massachusetts, 02215, United States
Bon Secours Liver Institute of Hampton Roads Mary Immaculate Hospital
TERMINATED

Newport News, Virginia, 23602, United States
Bon Secours Richmond Community Hospital LLC d/b/a Bon Secours Liver Institute of Richmond
RECRUITING

Richmond, Virginia, 23226, United States
CHI Health Clinic (Alegent Creighton Clinic)- Gastroenterology-Bergan
RECRUITING

Omaha, Nebraska, 68124, United States
CHU Grenoble - Hôpital MICHALLON
RECRUITING

Grenoble, 38043, France
CHU de NICE- Hospital L'Archet 2
RECRUITING

Nice, 06202, France
CRCHUM (Centre de Recherche du Centre Hospitalier de l'Université de Montréal)
RECRUITING

Montreal, H2X 0A9, Canada
Carmel Medical Center
RECRUITING

Haifa, 3434104, Israel
Cedars Sinai Medical Center
RECRUITING

Los Angeles, California, 90048, United States
Centro de Pesquisa Clínica da Bahiana Saúde
RECRUITING

Salvador, Estado de Bahia, 40290-000, Brazil
Centro de Pesquisas Clínicas do HC/UFMG-EBSERH
RECRUITING

Belo Horizonte, Minas Gerais, 30130-100, Brazil
Cleveland Clinic - Main Campus
RECRUITING

Cleveland, Ohio, 44195, United States
Cleveland Clinic Florida
RECRUITING

Weston, Florida, 33331, United States
Cliniques Universitaires Saint-Luc
RECRUITING

Brussels, 1200, Belgium
Clínica de Nefrología, Urología y Enfermedades Cardiovasculares
RECRUITING

Santa Fe, 3000, Argentina
Covenant Metabolic Specialists
TERMINATED

Fort Myers, Florida, 33912, United States
Covenant Research and Clinics, LLC
TERMINATED

Sarasota, Florida, 34240, United States
Ehime University Hospital
RECRUITING

Ehime, 791-0295, Japan
Einstein Healthcare Network - Einstein Medical Center
RECRUITING

Philadelphia, Pennsylvania, 19141, United States
Ente Ospedaliero Cantonale
RECRUITING

Lugano, 6900, Switzerland
Erasmus medical center
RECRUITING

Rotterdam, Netherlands
Fondazione Ca Granda
TERMINATED

Milan, 20122, Italy
Fondazione IRCCS San Gerardo dei Tintori
RECRUITING

Monza, 20900, Italy
Freeman Hospital
RECRUITING

Newcastle upon Tyne, NE7 7DN, United Kingdom
Fundação Oswaldo Ramos
RECRUITING

São Paulo, 04038-002, Brazil
Galen Medical Group, P.C
RECRUITING

Tennessee City, Tennessee, 37343, United States
Galilee Medical Center
RECRUITING

Nahariya, 2210001, Israel
Glenny Corp S.A
RECRUITING

CABA, 1430, Argentina
Gordon and Leslie Diamond Health Care Centre, Division of Gastroenterology
RECRUITING

Vancouver, British Columbia, V5Z 1M9, Canada
Hadassah Medical Center - Ein Karem, Liver Institute Kiryat Hadassah POB 12000
RECRUITING

Jerusalem, 9112001, Israel
Hillel Yaffe Medical Center
TERMINATED

Hadera, 3810101, Israel
Hopital Claude Huriez-Digestive system disease clinic
RECRUITING

Lille, 59037, France
Hospital Clínic de Barcelona
RECRUITING

Barcelona, 08036, Spain
Hospital Das Clínicas Da Ufg
RECRUITING

Goiânia, Goiás, 74605-050, Brazil
Hospital General Universitario Gregorio Maranon
RECRUITING

Madrid, 28007, Spain
Hospital Paul Brousse- APHP
RECRUITING

Villejuif, 94800, France
Hospital Provincial Del Centenario
RECRUITING

Rosario, Santa Fe Province, 2000, Argentina
Hospital Saint Antoine
RECRUITING

Paris, 75012, France
Hospital Universitari Parc Tauli
RECRUITING

Barcelona, 08208, Spain
Hospital Universitari Vall d' Hebron
RECRUITING

Barcelona, 08035, Spain
Hospital Universitario Miguel Servet
RECRUITING

Zaragoza, 50009, Spain
Hospital Universitario Virgen del Rocio
RECRUITING

Seville, 41013, Spain
Hospital Universitário Clementino Fraga Filho - Secretaria de Hepatologia
RECRUITING

Rio de Janeiro, 21941-617, Brazil
Hospital de Alta Complejidad En Red El Cruce
RECRUITING

San Juan Bautista, Buenos Aires, 1888, Argentina
Hospital de Clínicas de Porto Alegre
RECRUITING

Porto Alegre, Rio Grande do Sul, 90035903, Brazil
IHS Health
TERMINATED

Kissimmee, Florida, 34741, United States
Impact Research
TERMINATED

Waco, Texas, 76710, United States
Instituto de Educação, Pesquisa e Gestão em Saúde
RECRUITING

Rio de Janeiro, 22775-001, Brazil
Istituto Clinico Humanitas
RECRUITING

Rozzano, Italy
Jackson Liver and GI Specialists
TERMINATED

Jackson, Mississippi, 39216, United States
King's College Hospital NHS Foundation Trust
RECRUITING

London, SE5 9RS, United Kingdom
Klinikum Chemnitz gGmbH
RECRUITING

Chemnitz, 09116, Germany
LSU Health Science Center Shreveport
RECRUITING

Shreveport, Louisiana, 71103, United States
Liver Associates of Texas
RECRUITING

Houston, Texas, 77030, United States
Liver Institute Northwest
RECRUITING

Seattle, Washington, 98105, United States
Loyola University Health System - Loyola Outpatient Center
RECRUITING

Maywood, Illinois, 60153, United States
Massachusetts General Hospital
RECRUITING

Boston, Massachusetts, 02114, United States
Mayo Clinic
RECRUITING

Rochester, Minnesota, 55905, United States
McGill University Health Centre
RECRUITING

Montreal, Quebec, H4A 3J1, Canada
McMaster University Medical Center
RECRUITING

Hamilton, Ontario, L8S 4K1, Canada
MedStar Health Research Institute
RECRUITING

Fairfax, Virginia, 22031, United States
Medizinische Hochschule Hannover (MHH)
RECRUITING

Hanover, 30625, Germany
Mengchao Hepatobiliary Hospital of Fujian Medical University
RECRUITING

Fuzhou, Fujian, 350028, China
Methodist Le Bonheur Healthcare
TERMINATED

Memphis, Tennessee, 38104, United States
Montefiore Medical Center
RECRUITING

The Bronx, New York, 10467, United States
National Hospital Organization Nagasaki Medical Center
RECRUITING

Ōmura, Nagasaki, 856-8562, Japan
Northwestern University
TERMINATED

Chicago, Illinois, 60611, United States
Nottingham University Hospitals NHS Trust
RECRUITING

Nottingham, United Kingdom
Nouvel Hospital Civil
RECRUITING

Strasbourg, 67091, France
Ochsner Clinic Foundation-Baton Rouge
RECRUITING

Baton Rouge, Louisiana, 70836, United States
Osaka Rosai Hospital
RECRUITING

Osaka, 591-8025, Japan
Otto-von-Guericke-Universität Klinik für Gastroenterologie, Hepatologie und Infektiologie Universitätsklinikum Magdeburg A.ö.R.
RECRUITING

Magdeburg, 39120, Germany
Rabin Medical Center
RECRUITING

Petah Tikva, 4941492, Israel
Radboudumc
RECRUITING

Nijmegen, 6525 GA, Netherlands
Rambam Medical Center
RECRUITING

Haifa, 3109601, Israel
Royal Free Hospital NHS Foundation Trust
RECRUITING

London, NW3 2QZ, United Kingdom
Schiff Center for Liver Diseases
TERMINATED

Miami, Florida, 33136, United States
Science 37, Inc (Remote-homebased Telemedicine)
RECRUITING

Morrisville, North Carolina, 27560, United States
Shaare Zedek Medical Center
TERMINATED

Jerusalem, 9103102, Israel
Sheba Medical Center
RECRUITING

Ramat Gan, 52621, Israel
Sir Run Run Shaw Hospital -Zhejiang University School of Medicine
RECRUITING

Hangzhou, 310009, China
Soma Clinical Trials
TERMINATED

Denison, Texas, 75020, United States
Southeast Clinical Research Center
TERMINATED

Dalton, Georgia, 30720, United States
Southern California Research Center
TERMINATED

Coronado, California, 92218, United States
St. Josefs-Hospital Wiesbaden
ACTIVE_NOT_RECRUITING

Wiesbaden, 65189, Germany
Tampa General Hospital
RECRUITING

Tampa, Florida, 33606, United States
Teine Keijinkai Hospital
RECRUITING

Hokkaido, 006-8555, Japan
The First Affiliated Hospital, Zhejiang University School of Medicine
RECRUITING

Hangzhou, Zhejiang, 310003, China
The First Hospital of Jilin University
RECRUITING

Changchun, Jilin, 130031, China
The Liver Institute at Methodist Dallas Medical Center
RECRUITING

Dallas, Texas, 75203, United States
The Tel Aviv Sourasky Medical Center
TERMINATED

Tel Aviv, 6423906, Israel
Toranomon Hospital
RECRUITING

Tokyo, 105-8470, Japan
Toronto General Hospital
RECRUITING

Toronto, Ontario, M5G 1Z5, Canada
UC Davis
RECRUITING

Sacramento, California, 95817, United States
UF Health Gastroenterology- Emerson
TERMINATED

Jacksonville, Florida, 32209, United States
UF Hepatology Research at CTRB
RECRUITING

Gainesville, Florida, 32610, United States
UZ Gent
RECRUITING

Ghent, 9000, Belgium
Union Hospital Tongji Medical College Huazhong University of Science and Technology
RECRUITING

Wuhan, Hubei, 430022, China
Universita Politecnica delle Marche- Ospedali Riuniti
RECRUITING

Ancona, Italy
Universitair Ziekenhuis Antwerpe UZA
RECRUITING

Antwerp, 2650, Belgium
University Hospital Munster
RECRUITING

Münster, 48149, Germany
University Hospital Southampton NHS Foundation Trust
RECRUITING

Southampton, Hampshire, S016 6YD, United Kingdom
University Hospital Tübingen Medical clinic
RECRUITING

Tübingen, 72076, Germany
University Hospital Zurich(USZ)
RECRUITING

Zurich, 8091, Switzerland
University Hospital, LHSC
RECRUITING

London, Ontario, N6A5A5, Canada
University Hospitals Birmingham NHS Foundation Trust of Trust Headquarters
RECRUITING

Birmingham, West Midlands, B15 2GW, United Kingdom
University of Alberta
RECRUITING

Edmonton, T6G 2X8, Canada
University of California Los Angeles
RECRUITING

Los Angeles, California, 90095, United States
University of Colorado
RECRUITING

Aurora, Colorado, 80045, United States
University of Iowa Hospitals & Clinics
RECRUITING

Iowa City, Iowa, 52242, United States
University of Utah Health Care
RECRUITING

Salt Lake City, Utah, 84132, United States
Universitätsklinikum Frankfurt am Main
RECRUITING

Frankfurt, Germany
Universitätsklinikum Leipzig, Klinik und Poliklinik für Onkologie, Gastroenterologie, Hepatologie und Pneumologie
RECRUITING

Leipzig, 04103, Germany
Universitätsklinikum Schleswig-Holstein
RECRUITING

Kiel, 24105, Germany
Virtua Center for Liver Disease-Camden
RECRUITING

Camden, New Jersey, 08103, United States
Yale University Digestive Diseases
RECRUITING

New Haven, Connecticut, 06510, United States

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