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Vitamin e may shield the thyroid: a new trial tests the Antioxidant's power

NCT ID NCT07781514

Disease control Sponsor: Bangladesh Medical University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only This study
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 24, 2026 · Last updated Aug 26, 2026 · Updated 2 times

Summary

This trial tests whether adding vitamin E to standard levothyroxine treatment can reduce oxidative stress and improve thyroid function in adults with hypothyroidism. Participants will take either a vitamin E capsule or a placebo daily for 12 weeks. The study measures changes in thyroid hormone levels and markers of oxidative stress to see if this simple supplement could become a helpful addition to usual care.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
vitamin E (400 mg oral capsule daily for 12 weeks) as an add-on to levothyroxine therapy
What this could lead to
If effective, adding vitamin E to standard levothyroxine treatment could help reduce oxidative stress and improve thyroid hormone balance in people with hypothyroidism.
What could go wrong
This is a small, early-stage trial, and vitamin E may not significantly change thyroid function or oxidative stress. High doses of vitamin E can also carry risks, such as bleeding, especially in certain individuals.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 74 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Feb 2027

An estimate. Start dates often move.

Expected to finish

Jul 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age above 18 years up to 75 years * Patient receiving Levothyroxine for at least 12 weeks * Both male and female patient Exclusion Criteria: * Pregnancy or lactating mother * Suffering from active malignancy * Known hypersensitivity to vitamin E * Patient taking any other antioxidant drug * Patients taking any antiplatelet or anticoagulant drug * Patient with acute illness, liver disease, psychiatric disorder, hyperlipidemia

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Conditions

The condition(s) this trial relates to.

hypothyroidism

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Hypothyroidism

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Bangladesh Medical University

    Dhaka, Bangladesh

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