Blood tests and PET scans put to the test against dangerous artery infections
NCT ID NCT07847346
First seen Sep 29, 2026 · Last updated Oct 02, 2026 · Updated 2 times
Summary
Vascular infections are rare but serious conditions that affect the artery wall, bypass grafts, or stents. Researchers at Zhongshan Hospital in Shanghai are following 2,000 adults with suspected or confirmed vascular infections to see how well blood-based pathogen detection and 18F-FDG PET/CT imaging diagnose the infection and track treatment response. The study also collects blood and tissue samples to look for biomarkers linked to cure, recurrence, and death over five years. The goal is to improve how doctors identify the cause, monitor treatment, and predict which patients will recover.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If the approach works, doctors could detect vascular infections faster through blood tests and use PET/CT scans to judge whether treatment is working. That may help more patients reach a lasting cure without lifelong antibiotics.
- What could go wrong
- This is an observational study at one hospital, so it cannot prove that any test or scan improves outcomes. Findings from 2,000 patients in Shanghai may not apply to other hospitals or populations.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 2,000 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Nov 2026
An estimate. Start dates often move.
- Expected to finish
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Nov 2041
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
The study population consists of consecutive adult patients evaluated or treated at Zhongshan Hospital, Fudan University, for suspected or confirmed vascular infections involving the native arterial wall, vascular grafts, or endografts. The cohort includes infectious aortitis, infected arterial aneurysms, vascular graft or endograft infections, and fistula-associated vascular infections. The ambispective design includes retrospectively identified patients with adequate clinical records and prospectively enrolled patients undergoing longitudinal follow-up. Clinical, microbiological, imaging, treatment, and outcome data will be collected, and biospecimens will be retained when available. Final diagnostic classification will be determined by multidisciplinary adjudication integrating clinical presentation, microbiological and molecular findings, imaging, pathology, operative findings, and longitudinal clinical course.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Adults aged 18 years or older. 2. Patients with suspected or confirmed vascular infection involving the native arterial wall, vascular graft, or endograft, including but not limited to infectious aortitis, infected arterial aneurysm, vascular graft or endograft infection, and fistula-associated vascular infection. 3. Patients evaluated or treated at Zhongshan Hospital, Fudan University, with sufficient clinical information to allow diagnostic adjudication and outcome assessment. 4. For the prospective cohort, willingness to participate and provide informed consent when required. 5. For the retrospective cohort, availability of relevant clinical records meeting the requirements approved by the institutional ethics committee. Exclusion Criteria: 1. Isolated superficial surgical-site infection without evidence of involvement of the arterial wall, vascular graft, or endograft. 2. Insufficient clinical data to permit diagnostic adjudication or longitudinal outcome assessment. 3. Refusal to participate in the prospective component when informed consent is required.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Zhongshan Hospital, Fudan University
RECRUITINGShanghai, 200032, China
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