New hope for Tough-to-Treat lymphoma: experimental drug shows promise in Mid-Stage trial

NCT ID NCT04703192

Ongoing Disease control Sponsor: Daiichi Sankyo Source: ClinicalTrials.gov ↗

First seen Jan 07, 2026 · Last updated May 13, 2026 · Updated 13 times

Summary

This study tests a drug called valemetostat tosylate in people with a rare type of blood cancer (peripheral T-cell lymphoma) that has returned or not improved after other treatments. About 155 adults will take the drug and be monitored for tumor shrinkage and side effects. The goal is to see if the drug can control the cancer, though it is not expected to be a cure.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

A.O.di Bologna Policl.S.Orsola

Bologna, 40138, Italy
APHP - Hopital Saint Louis

Paris, 75010, France
ASST Papa Giovanni XXIII - Medicina Trasfusionale ed Ematologia - Bergamo

Bergamo, 24127, Italy
Asan Medical Center - Oncology

Seoul, 05505, South Korea
BC Cancer - Vancouver Centre

Vancouver, British Columbia, V5Z 4E6, Canada
CHRU de Lille - Hôpital Claude Huriez - Maladies du Sang

Lille, 59037, France
CHU de Dijon

Dijon, 21079, France
Centre Hospitalier Lyon Sud - Hématologie

Pierre-Bénite, 69495, France
Centre Lyon Berard - Medical Oncology

Lyon, 69008, France
Chang Gung Medical Foundation - Kaohsiung Chang Gung Memorial Hospital - Hemato-Oncology

Kaohsiung City, 83301, Taiwan
Chang Gung Medical Foundation - LinKou Chang Gung Memorial Hospital - Hematology and Oncology - Hematology and Oncology

Taoyuan City, 33305, Taiwan
Churchill Hospital

Oxford, OX3 7LE, United Kingdom
City Of Hope National Medical Center

Duarte, California, 91010, United States
Dana Farber Cancer Institute

Boston, Massachusetts, 02115, United States
Duke Cancer Center

Durham, North Carolina, 27710, United States
Emory University Hospital - Winship Cancer Institute

Atlanta, Georgia, 30322, United States
Epworth Healthcare

Richmond, 3121, Australia
Fondazione Pascale, IRCCS, Istituto Nazionale dei Tumori

Naples, 80131, Italy
Hackensack University Medical Center - John Theurer Cancer Center

Hackensack, New Jersey, 07601, United States
Hokkaido University Hospital - Medical Oncology Center

Sapporo, Hokkaido, 060-8648, Japan
Hospital Universitario Fundación Jiménez Díaz

Madrid, 28040, Spain
Hospital Universitario La Paz

Madrid, 28046, Spain
Hospital Universitario Vall d'Hebrón

Barcelona, 08035, Spain
Hospital Universitario Virgen del Rocio

Seville, 41013, Spain
Hôpital Necker

Paris, 75015, France
ICO Hospital Duran i Reynals

Barcelona, 08029, Spain
Institut Universitaire du Cancer de Toulouse-Oncopole (IUCT-Oncopole)

Toulouse, 31100, France
Kagoshima University Hospital

Kagoshima, 890-8520, Japan
Kyushu University Hospital

Fukuoka, 812-0054, Japan
Leids Universitair Medisch Centrum (LUMC) (Leiden University Medical Center)

Leiden, 2333ZA, Netherlands
Mayo Clinic - Rochester

Rochester, Minnesota, 55901, United States
Memorial Sloan-Kettering Cancer Center at Memorial Hospital

New York, New York, 10065, United States
Nagasaki University Hospital

Nagasaki, 852-8501, Japan
Nagoya City University Hospital

Nagoya, Aichi-ken, 467-8602, Japan
National Cancer Center Hospital

Chuo Ku, Tokyo, 104-0045, Japan
National Cancer Center Hospital East

Kashiwa, Chiba, 277-8577, Japan
National Cheng Kung University Hospital - Internal Medicine

Tainan, 70403, Taiwan
National Hospital Organization Nagoya Medical Center - Hematology

Nagoya, Aichi-ken, 460-0001, Japan
National Taiwan University Hospital - Hematology And Oncology

Taipei, 10002, Taiwan
Northwestern University - Feinberg School of Medicine

Chicago, Illinois, 60611, United States
Nottingham City Hospital - Clinical Haematology

Nottingham, NG5 1PB, United Kingdom
Okayama University Hospital

Okayama, 700-8558, Japan
Ospedale S.Maria della Misericordia, AO di Perugia, Università degli Studi di Perugia

Perugia, 06132, Italy
Ottawa Hospital Research Institute

Ottawa, K1H 8L6, Canada
PO San Gerardo, ASST Monza

Monza, 20900, Italy
Samsung Medical Center - Hematology-Oncology

Seoul, 06351, South Korea
Seoul National University Hospital - Department of Internal

Seoul, 03080, South Korea
Severance Hospital, Yonsei University Health System

Seoul, Seoul Teugbyeolsi, 03722, South Korea
Stanford University Medical Center - Cancer Clinical Trials Office - ONCOLOGY

Palo Alto, California, 94304, United States
The Catholic University of Korea, Seoul St. Mary's Hospital

Seoul, 06591, South Korea
Universiteit Maastricht Academisch Ziekenhuis Maastricht

Maastricht, 6229 HX, Netherlands
University College London Hospital

London, NW1 2PG, United Kingdom
University Health Network Princess Margaret Hospital

Toronto, M5G 1Z5, Canada
University Hospital - Kyoto Prefectural University of Medicine

Kyoto, 602-8566, Japan
University Of Colorado Cancer Center

Aurora, Colorado, 80045, United States
University of California San Francisco

San Francisco, California, 94143, United States
University of Pennsylvania Perelman Center for Advanced Medicine

Philadelphia, Pennsylvania, 19104, United States
Universitätsklinikum Halle (Saale) - Klinik und Poliklinik für Innere Medizin IV

Halle, 06120, Germany
Washington University School of Medicine

St Louis, Missouri, 63110, United States
Weill Cornell Medicine

New York, New York, 10065, United States

Conditions

Explore the condition pages connected to this study.

ADULT T-CELL LEUKEMIA-LYMPHOMA ADULT T-CELL LEUKEMIA/LYMPHOMA RELAPSED/REFRACTORY PERIPHERAL T CELL LYMPHOMA