Scientists test vaccine to stop cancer before it starts in High-Risk patients
NCT ID NCT05419011
Summary
This study is testing whether a combination of a three-part vaccine and an immune system booster can prevent colon and other cancers in people with Lynch syndrome, a genetic condition that greatly increases cancer risk. The vaccine aims to train the body's immune system to recognize and destroy precancerous cells before they turn into cancer. About 186 participants will receive either the vaccine combination or a placebo and be monitored for two years with regular colonoscopies.
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Contacts and locations
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Locations
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Cleveland Clinic Foundation
Cleveland, Ohio, 44195, United States
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Dana-Farber Cancer Institute
Boston, Massachusetts, 02215, United States
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Fox Chase Cancer Center
Philadelphia, Pennsylvania, 19111, United States
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M D Anderson Cancer Center
Houston, Texas, 77030, United States
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Mayo Clinic Hospital in Arizona
Phoenix, Arizona, 85054, United States
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Mayo Clinic in Rochester
Rochester, Minnesota, 55905, United States
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Northwestern University
Chicago, Illinois, 60611, United States
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Ohio State University Comprehensive Cancer Center
Columbus, Ohio, 43210, United States
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UCSF Medical Center-Parnassus
San Francisco, California, 94143, United States
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University of Arizona Cancer Center - Prevention Research Clinic
Tucson, Arizona, 85719, United States
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University of Colorado
Denver, Colorado, 80217-3364, United States
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University of Kansas Cancer Center
Kansas City, Kansas, 66160, United States
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University of Michigan Rogel Cancer Center
Ann Arbor, Michigan, 48109, United States
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University of Puerto Rico
San Juan, 00936, Puerto Rico
Conditions
Explore the condition pages connected to this study.