Lifestyle overhaul tested as fatty liver fix
NCT ID NCT07652151
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
The UNMASK study is testing whether a 16-week program of Mediterranean diet and regular exercise can reduce liver fat and scarring in people with metabolic fatty liver disease (MASLD). Researchers will enroll 450 adults and track changes in liver health using scans and blood tests. The goal is to see if lifestyle changes alone can improve this common condition.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Mediterranean diet plus structured exercise (150 min/week moderate or 75 min/week high-intensity)
What this could lead to
If successful, this could show that a simple lifestyle program can reduce liver fat and scarring in people with fatty liver disease, pointing toward a non-drug treatment option.
What could go wrong
This is an early-stage observational study with no control group, so results may not prove cause and effect. The lifestyle changes are intensive and may be hard for many to maintain long-term.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Fondazione Policlinico Universitario Agostino Gemelli IRCCS. Internal Medicine and Liver Transplantation Unit
NOT_YET_RECRUITINGRoma, Italy
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hacettepe University
NOT_YET_RECRUITINGAnkara, Turkey (Türkiye)
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hospital Universitario Virgen del Rocío de Sevilla
RECRUITINGSeville, Spain
Contact Email: •••••@•••••
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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