Can breathing training help ventilator patients breathe on their own?

NCT ID NCT04658498

Recruiting now Knowledge-focused Sponsor: KU Leuven Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at how different types of breathing muscle training affect patients in the ICU who are having trouble coming off a ventilator. Researchers will compare usual care with two forms of inspiratory muscle training (one high-intensity, one low-intensity) in 90 adults. The goal is to understand how the breathing muscles change and improve, not to test a new drug or device.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Inspiratory muscle training using a tapered flow resistive device (POWERbreathe KH2)
What this could lead to: If successful, this study could point toward better, more effective ways to help ICU patients breathe on their own again after being on a ventilator.
What could go wrong: This is a small, early-stage mechanistic study (90 participants) focused on understanding muscle changes, not on proving a treatment works. Results may not lead to a clear clinical benefit.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

WEANING FAILURE

Contacts and locations

Locations

University Hospital Leuven
RECRUITING

Leuven, 3000, Belgium

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