Could a bone marrow shield make chemotherapy safer for lung cancer patients?
NCT ID NCT02514447
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested a drug called trilaciclib in 123 people with advanced small cell lung cancer who were getting chemotherapy. The goal was to see if trilaciclib could protect the bone marrow and immune system from chemotherapy damage, reducing severe side effects like low white blood cell counts. The study had two parts: an initial open-label dose-finding phase and a larger randomized double-blind phase.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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AZ Klina
Brasschaat, 2930, Belgium
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AnMed Health
Anderson, South Carolina, 29621, United States
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Clinic for Pulmology, Clinical Centre of Serbia
Belgrade, 11000, Serbia
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Clinical Center Nis, Clinic for Lung Diseases
Niš, 18204, Serbia
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Clinical Hospital Centre Bezanijska Kosa
Belgrade, 11000, Serbia
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Clinical Hospital Centre Osijek
Osijek, 31000, Croatia
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Compassionate Cancer Care Medical Group, Inc.
Corona, California, 92879, United States
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Emory University
Atlanta, Georgia, 30322, United States
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Florida Cancer Specialists - North
Tavares, Florida, 32778, United States
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Florida Cancer Specialists - South
Fort Myers, Florida, 33916, United States
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Gabrail Cancer Center
Canton, Ohio, 44718, United States
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Genesis Cancer Center
Hot Springs, Arkansas, 71913, United States
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Gibbs Cancer Center
Spartanburg, South Carolina, 29303, United States
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Greenville Health System
Greenville, South Carolina, 29605, United States
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Guthrie Medical Group, PC
Sayre, Pennsylvania, 18840, United States
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Hanna Cancer Associates - University of Tennessee
Knoxville, Tennessee, 37920, United States
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Highlands Oncology Group
Rogers, Arkansas, 72758, United States
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Institute for Pulmonary Diseases of Vojvodina Clinic for Thoracic Oncology
Kamenitz, 21204, Serbia
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M.D. Anderson
Houston, Texas, 77030, United States
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Meharry Medical College
Nashville, Tennessee, 37208, United States
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Memorial Hospital - University of Colorado Health
Colorado Springs, Colorado, 80909, United States
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Millennium Oncology
Houston, Texas, 77090, United States
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Norris Cotton Cancer Center
Lebanon, New Hampshire, 03756, United States
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North Shore Hematology Oncology Associates PC
East Setauket, New York, 11733, United States
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Northside Hospital - Georgia Cancer Specialists
Atlanta, Georgia, 30341, United States
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Northwest Cancer Specialists, P.C.
Vancouver, Washington, 98684, United States
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Oklahoma University - Peggy and Charles Stephenson Cancer Center
Oklahoma City, Oklahoma, 73117, United States
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Oncology and Radiology Institute of Serbia
Belgrade, 11000, Serbia
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POKO POPRAD, s.r.o.
Poprad, 05801, Slovakia
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Regional Medical Oncology Center
Wilson, North Carolina, 27893, United States
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Rocky Mountain Cancer Centers
Denver, Colorado, 80218, United States
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Saint Luke's Cancer Institute
Kansas City, Missouri, 64111, United States
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Sarah Cannon Research Institute
Nashville, Tennessee, 37232, United States
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Southwest Cancer Center
Lubbock, Texas, 79415, United States
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Sutter Medical Group
Sacramento, California, 95816, United States
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Texas Oncology
Tyler, Texas, 75702, United States
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Texas Oncology- Baylor Charles A. Sammons Cancer Center
Dallas, Texas, 75246, United States
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The Oncology Institute of Hope and Innovation
Whittier, California, 90603, United States
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The University of Texas Health Science Center at Tyler
Tyler, Texas, 75708, United States
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University Cancer and Blood Center, LLC
Athens, Georgia, 30607, United States
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University Clinic of Radiotherapy and Oncology Skopje
Skopje, 1000, North Macedonia
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University Clinic of Respiratory and Allergic Diseases Golnik
Golnik, Slovenia
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University Clinical Centre Banja Luka
Banja Luka, 78000, Bosnia and Herzegovina
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University Clinical Centre Sarajevo
Sarajevo, 71000, Bosnia and Herzegovina
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University Clinical Hospital Centre " Sestre Milosrdnice"
Zagreb, 10000, Croatia
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University Hospital Centre Zagreb, Clinic For Pulmonary Diseases Jordanovac
Zagreb, 10000, Croatia
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University of Colorado Health, Oncology Clinical Research Northern Region
Fort Collins, Colorado, 80528, United States
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VOU Department of Radiotherapy and Oncology
Košice, 04191, Slovakia
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Virginia Cancer Specialists
Fairfax, Virginia, 22031, United States
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Virginia Oncology Associates
Norfolk, Virginia, 23502, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Could adding chest radiation extend life in advanced lung cancer?
- Can a pill restore the Body's tumor suppressor to fight multiple cancers?
- Can a new drug tame advanced solid tumors?
- Can a remote approach bring clinical trials to lung cancer patients?
- Which palliative care approach boosts quality of life in advanced lung cancer?