Can a mouth rinse save your taste buds during cancer treatment?

NCT ID NCT06500884

Recruiting now Symptom relief Sponsor: Janssen Research & Development, LLC Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jul 31, 2026 · Updated 4 times

Summary

This study tests whether certain mouth rinses or oral medications can prevent or reduce taste changes caused by the drug talquetamab, used to treat multiple myeloma. About 210 participants will be randomly assigned to different preventive treatments. The goal is to find a way to keep patients' sense of taste intact during therapy.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Talquetamab (a drug) and various mouth rinses or oral medications to prevent taste changes
What this could lead to: If successful, this study could identify a way to prevent or reduce the unpleasant taste changes that often come with talquetamab treatment, making it easier for patients to tolerate.
What could go wrong: This is a phase 2 trial, so it's still early. The preventive treatments may not work well for everyone, and taste changes might still occur. The study focuses on managing side effects, not on curing the cancer itself.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

plasma cell myeloma refractory plasma cell neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MULTIPLE MYELOMA REFRACTORY MULTIPLE MYELOMA RELAPSE MULTIPLE MYELOMA

Contacts and locations

Locations

Albert Schweitzer Ziekenhuis
RECRUITING

Dordrecht, 3318 AT, Netherlands
Belfast City Hospital
RECRUITING

Belfast, BT9 7AB, United Kingdom
Clinica Medica Sao Germano S/S LTDA
RECRUITING

São Paulo, 01455 010, Brazil
Colchester Hospital University NHS
RECRUITING

Colchester, CO4 5JL, United Kingdom
Colorado Blood Cancer Institute
RECRUITING

Denver, Colorado, 80218, United States
Duke University Medical Center
RECRUITING

Durham, North Carolina, 27705, United States
Eastbourne District General Hospital
RECRUITING

Eastbourne, BN21 2UD, United Kingdom
Erasmus MC
RECRUITING

Rotterdam, 3015 CN, Netherlands
Fundacao Universidade de Caxias do Sul
RECRUITING

Caxias do Sul, 95070 560, Brazil
Hammersmith Hospital
RECRUITING

London, W12 0HS, United Kingdom
Hosp Clinic de Barcelona
RECRUITING

Barcelona, 08036, Spain
Hosp Clinico Univ de Salamanca
RECRUITING

Salamanca, 37007, Spain
Hosp. Quiron Madrid Pozuelo
RECRUITING

Pozuelo de Alarcón, 28223, Spain
Hosp. Univ. 12 de Octubre
RECRUITING

Madrid, 28041, Spain
Hosp. Univ. Germans Trias I Pujol
RECRUITING

Badalona, 08916, Spain
Hosp. Univ. Ramon Y Cajal
RECRUITING

Madrid, 28034, Spain
Hosp. Univ. Virgen de La Arrixaca
RECRUITING

El Palmar, 30120, Spain
Hosp. de Jerez de La Frontera
RECRUITING

Jerez de la Frontera, 11407, Spain
Hospitais Integrados da Gavea SA DF Star
RECRUITING

Brasília, 70390-140, Brazil
Hospital Erasto Gaertner- Liga Paranaense de Combate ao Cancer
RECRUITING

Curitiba, 81520-060, Brazil
Hospital Espanol Auxilio Mutuo Auxilio Mutuo Cancer Center
RECRUITING

San Juan, 00918, Puerto Rico
Icahn School of Medicine at Mt. Sinai
RECRUITING

New York, New York, 10029, United States
Instituto D Or de Pesquisa e Ensino
RECRUITING

Salvador, 41253 190, Brazil
Instituto D Or de Pesquisa e Ensino IDOR
RECRUITING

São Paulo, 04543-000, Brazil
Newcastle Freeman Hospital
COMPLETED

Newcastle upon Tyne, NE7 7DN, United Kingdom
Samsung Medical Center
RECRUITING

Seoul, 135-230, South Korea
Seoul National University Hospital
RECRUITING

Seoul, 03080, South Korea
The Catholic University of Korea Seoul St Mary s Hospital
RECRUITING

Seoul, 06591, South Korea
The Christie NHS Foundation Trust Christie Hospital
RECRUITING

Manchester, M20 4BX, United Kingdom
The Clatterbridge Cancer Centre
RECRUITING

Liverpool, L7 8YA, United Kingdom
University College London Hospitals
RECRUITING

London, NW1 2BU, United Kingdom
University Hospitals Cleveland Medical Center
RECRUITING

Cleveland, Ohio, 44106, United States
University of California San Francisco
RECRUITING

San Francisco, California, 94143, United States
University of Rochester Medical Center
RECRUITING

Rochester, New York, 14642, United States
University of Washington
RECRUITING

Seattle, Washington, 98109, United States
VUMC Amsterdam
RECRUITING

Amsterdam, 1081 HV, Netherlands
Virginia Commonwealth University - Massey Cancer Center
RECRUITING

Richmond, Virginia, 23298, United States
Yale University School Of Medicine
RECRUITING

New Haven, Connecticut, 06510, United States

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