Scientists dive into bone marrow to unlock vaccine memory secrets
NCT ID NCT07493460
First seen Apr 30, 2026 · Last updated Jun 22, 2026 · Updated 7 times
Summary
This study looks at how the immune system 'remembers' vaccines by tracking special cells in the bone marrow. Twenty-five healthy adults will receive four different vaccines at once and give blood, bone marrow, and lymph node samples over two years. The goal is to understand why some vaccine protection lasts longer than others.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Washington University School of Medicine Infectious Disease Clinical Research Unit
St Louis, Missouri, 63110, United States
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
trivalent inactivated influenza vaccine (TIV), nonavalent HPV vaccine, hepatitis A vaccine, tetanus/diphtheria/pertussis vaccine (Tdap)
What this could lead to
If successful, this could help scientists design better vaccines that provide longer-lasting protection.
What could go wrong
This is a small, early-phase observational study with only 25 healthy adults, so results may not apply to everyone. The bone marrow and lymph node procedures are invasive and carry minor risks like pain or infection.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.