Scientists dive into bone marrow to unlock vaccine memory secrets

NCT ID NCT07493460

Ongoing Knowledge-focused Sponsor: Washington University School of Medicine Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 02, 2026 · Updated 2 times

Summary

This study looks at how the immune system 'remembers' vaccines by tracking special cells in the bone marrow. Twenty-five healthy adults will receive four different vaccines at once and give blood, bone marrow, and lymph node samples over two years. The goal is to understand why some vaccine protection lasts longer than others.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: trivalent inactivated influenza vaccine (TIV), nonavalent HPV vaccine, hepatitis A vaccine, tetanus/diphtheria/pertussis vaccine (Tdap)
What this could lead to: If successful, this could help scientists design better vaccines that provide longer-lasting protection.
What could go wrong: This is a small, early-phase observational study with only 25 healthy adults, so results may not apply to everyone. The bone marrow and lymph node procedures are invasive and carry minor risks like pain or infection.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

immune system disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEALTHY ADULTS IMMUNOLOGY

Contacts and locations

Locations

Washington University School of Medicine Infectious Disease Clinical Research Unit

St Louis, Missouri, 63110, United States

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