New drug combo aims to tame chronic hepatitis b

NCT ID NCT06706310

Ongoing Disease control Sponsor: Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This Phase 2 trial tests whether adding TQ-A3334 tablets to standard nucleoside analog drugs can better control chronic hepatitis B. About 116 adults with the infection will receive either the combination or a placebo plus standard drugs. The main goal is to see if the combination lowers a key virus marker (HBsAg) in the blood after 24 weeks of treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: TQ-A3334 tablet combined with nucleoside analogs
What this could lead to: If successful, this combination could help control chronic hepatitis B more effectively, potentially reducing the virus's activity and improving liver health.
What could go wrong: This is an early Phase 2 trial with only 116 people, so results may not apply broadly. The treatment may not significantly lower HBsAg levels, and side effects are still being studied.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

chronic hepatitis B virus infection hepatitis B virus infection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC HEPATITIS B

Contacts and locations

Locations

First People's Hospital of Yunnan Province

Kunming, Yunnan, 650034, China
Hospital workers in Liuzhou

Liuzhou, Guangxi, 545000, China
Peking University Shenzhen Hospital

Shenzhen, Guangdong, 518036, China
People's Hospital Of RuiAn City

Rui’an, Zhejiang, 325200, China
Pu'er People's Hospital

Pu'er, Yunnan, 665099, China
The Fifth People's Hospital of Wuxi (Affiliated Wuxi Fifth Hospital of Jiangnan University)

Wuxi, Jiangsu, 214001, China
The First Affiliated Hospital of Chongqing Medical University

Chongqing, Chongqing Municipality, 400016, China
The First Affiliated Hospital of Xi'an Jiao Tong University

Xi'an, Shaanxi, 710000, China
The First Affiliated Hospital of Xinjiang Medical University

Ürümqi, Xinjiang, 831400, China
The Second XIANGYA Hospital Of Central South University

Changsha, Hunan, 410008, China
The Sixth People's Hospital of Shenyang

Shenyang, Liaoning, 110000, China
The Third Affiliated Hospital of Sun Yat-sen University

Guangzhou, Guangdong, 510000, China
The first hospital of Jilin University

Changchun, Jilin, 130021, China
West China Hospital of Sichuan University

Chengdu, Sichuan, 610044, China
WuHan Jinyintan Hospital

Wuhan, Hubei, 430023, China

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