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Could a simple cream ease chronic pelvic pain?

NCT ID NCT07257029

Recruiting now Symptom relief Sponsor: Center for Vulvovaginal Disorders Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests a cream called ketotifen fumarate for women who experience sharp or burning pain during vaginal penetration, a condition known as secondary vestibulodynia. About 54 women will apply the cream or a placebo to the painful area twice daily for 12 weeks. Researchers will measure changes in pain levels and quality of life to see if the cream helps.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
ketotifen fumarate 0.25% cream
What this could lead to
If it works, this could offer a non-surgical, topical treatment to reduce pain during intercourse for women with secondary vestibulodynia.
What could go wrong
This is an early Phase 2 trial with only 54 participants. The cream may not reduce pain better than placebo, and results may not apply to all women with the condition.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

vulvodynia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

INSTERTIONAL DYSPAREUNIA MAST CELL-MEDIATED NEUROINFLAMMATION NEUROPROLIFERATIVE VESTIBULODYNIA PROVOKED VESTIBULODYNIA SECONDARY PROVOKED VESTIBULODYNIA VULVARY PAIN DISORDERS VULVODYNIA

Contacts and locations

Locations

  • The Center for Vulvovaginal Disorders

    RECRUITING

    Tampa, Florida, 33609, United States

  • The Center for Vulvovaginal Disorders - New York

    RECRUITING

    New York, New York, 10036, United States

  • The Center for Vulvovaginal Disorders - Washington, DC

    RECRUITING

    Washington D.C., District of Columbia, 20037, United States

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