Cure My Disease

Don't miss your cure!

 Log in / Sign up

New drug combo aims to treat bladder cancer without chemo

NCT ID NCT05645692

Ongoing Disease control Sponsor: Hoffmann-La Roche Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This Phase 2 trial tests two new immunotherapy drugs, tobemstomig alone or with tiragolumab, against the standard drug atezolizumab. It includes 204 people with advanced bladder cancer who cannot have platinum chemotherapy. The main goal is to check safety and side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
tobemstomig (alone or with tiragolumab) compared to atezolizumab
What this could lead to
If successful, this could offer a new immunotherapy option for people with advanced bladder cancer who cannot take standard chemotherapy.
What could go wrong
This is an early Phase 2 trial with only 204 participants, so results may not confirm benefit. Immunotherapies can cause immune-related side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for METASTATIC UROTHELIAL CANCER are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

urothelial carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

UROTHELIAL CANCER

Contacts and locations

Locations

  • *X*CEPHO - Centro de Estudos e Pesquisas em Hematologia e Oncologia

    Santo André, São Paulo, 09060-650, Brazil

  • A.O. Universitaria Ospedale Consorziale Policlinico Di Bari

    Bari, Apulia, 70124, Italy

  • Aarhus Universitetshospital

    Aarhus N, 8200, Denmark

  • Adana Baskent University Medical Faculty

    Adana, 01220, Turkey (Türkiye)

  • Alexandras General Hospital of Athens

    Athens, 115 28, Greece

  • Ankara City Hospital

    Ankara, 06800, Turkey (Türkiye)

  • Asan Medical Center

    Seoul, 05505, South Korea

  • Attikon University General Hospital

    Chaïdári, 124 62, Greece

  • Azienda Ospedaliera S. Maria - Terni

    Terni, Umbria, 05100, Italy

  • Azienda Ospedaliero-Universitaria S.Orsola-Malpighi

    Bologna, Emilia-Romagna, 40138, Italy

  • Barts and the London NHS Trust

    London, E1 2ES, United Kingdom

  • Beijing Cancer Hospital

    Beijing, 100142, China

  • Centre Leon Berard

    Lyon, 69373, France

  • Cleveland Clinic

    Cleveland, Ohio, 44106, United States

  • Gachon University Gil Medical Center

    Incheon, 21565, South Korea

  • Goztepe Prof.Dr. Suleyman Yalcin City Hospital

    Kadiköy, 34722, Turkey (Türkiye)

  • Gustave Roussy

    Villejuif, 94800, France

  • Health Pharma Professional Research

    Mexico City, Mexico CITY (federal District), 03100, Mexico

  • Herlev Hospital

    Herlev, 2730, Denmark

  • Hospital Alemao Oswaldo Cruz

    São Paulo, São Paulo, 01323-903, Brazil

  • Hospital Universitario 12 de Octubre

    Madrid, 28041, Spain

  • Hospital Universitario Clínico San Carlos

    Madrid, 28040, Spain

  • Hospital Universitario Evangelico De Curitiba

    Curitiba, Paraná, 80440-220, Brazil

  • Hospital Universitario La Paz

    Madrid, 28046, Spain

  • Hospital das Clinicas - UFRGS

    Porto Alegre, Rio Grande do Sul, 90035-903, Brazil

  • Hospital de Amor Amazônia

    Porto Velho, Rondônia, 76834-899, Brazil

  • Hospital de Madrid Norte Sanchinarro- Centro Integral Oncologico Clara Campal

    Madrid, 28050, Spain

  • ICON Cancer Care Adelaide

    Kurralta Park, South Australia, 5037, Australia

  • IRCCS Istituto Oncologico Veneto (IOV)

    Padova, Veneto, 35128, Italy

  • IRST Istituto Scientifico Romagnolo Per Lo Studio E Cura Dei Tumori, Sede Meldola

    Meldola, Emilia-Romagna, 47014, Italy

  • Institut Catala d Oncologia Hospital Duran i Reynals

    Barcelona, 08908, Spain

  • Irccs Ospedale San Raffaele

    Milan, Lombardy, 20132, Italy

  • Istituto Nazionale Tumori Irccs Fondazione G. Pascale

    Naples, Campania, 80131, Italy

  • Izmir Medical Point Hospital

    Izmir, 35101, Turkey (Türkiye)

  • Krankenhaus Martha-Maria Halle-Dölau, Klinik für Urologie

    Halle, 06120, Germany

  • Lyell McEwin Hospital

    Adelaide, South Australia, 5112, Australia

  • MD Anderson Cancer Center

    Houston, Texas, 77030, United States

  • Macquarie University Hospital

    Macquarie Park, New South Wales, 2113, Australia

  • Martini-Klinik am UKE GmbH

    Hamburg, 20246, Germany

  • Policlinico Universitario "Agostino Gemelli"

    Rome, Lazio, 00168, Italy

  • Pratia Poznan

    Późna, 60-192, Poland

  • Royal Marsden Hospital (Sutton)

    Sutton, SM2 5PT, United Kingdom

  • Royal Preston Hosptial

    Preston, PR2 9HT, United Kingdom

  • Ruijin Hospital, Shanghai Jiaotong University School of Medicine

    Shanghai, 200025, China

  • Samsung Medical Center

    Seoul, 06351, South Korea

  • Seoul National University Bundang Hospital

    Gyeonggi-do, South Korea

  • Seoul National University Hospital

    Seoul, 03080, South Korea

  • Severance Hospital, Yonsei University

    Seoul, 03722, South Korea

  • Sun yat-sen University Cancer Center

    Guangzhou, 510060, China

  • Szpital Grochowski im. dr med. Rafa?a Masztaka Sp. z o.o.

    Warsaw, 04-073, Poland

  • Szpital Uniwersytecki w Krakowie

    Krakow, 31-501, Poland

  • Szpital Wojewódzki im. Miko?aja Kopernika

    Koszalin, 75-581, Poland

  • Theageneio Hospital

    Thessaloniki, 54007, Greece

  • Trakya Universitesi Tip Fakultesi, Medikal Onkoloji Bilim Dali, Balkan Yerleskesi

    Edirne, 22030, Turkey (Türkiye)

  • Vall d'Hebron Institute of Oncology (VHIO), Barcelona

    Barcelona, 08035, Spain

  • West China Hospital - Sichuan University

    Chengdu, 610047, China

More trials for these conditions

Other studies related to the condition(s) this trial covers.