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Tiny study on nerve surgery for amputees halted early

NCT ID NCT04658368

Symptom relief Sponsor: University of Wisconsin, Madison Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early This study
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study aimed to measure how targeted muscle reinnervation (TMR) surgery affects quality of life and function in people who have had a major limb amputation. TMR was done either at the time of amputation or later. Only 2 people took part before the study was stopped early, so the findings are very limited.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Targeted muscle reinnervation (TMR) surgery
What this could lead to
If successful, this could show that TMR improves quality of life and function for people with major limb amputations.
What could go wrong
The study was terminated early with only 2 participants, so results are very limited and may not apply to others. It was also a small, single-center study.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

2 people

The number who actually took part.

Started

Dec 2020

Finished

Sep 2022

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients that have undergone (retrospective) or are scheduled to undergo (prospective) major limb amputation with primary or secondary TMR procedure at the UW. A control group of participants that have had major limb amputation at the UW without the TMR procedure will also be surveyed.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Study cohort * Retrospective * Underwent primary or secondary TMR with attending plastic surgeon at UW * Prospective * Patient with history of major limb amputation who is scheduled to undergo secondary TMR with attending plastic surgeon at UW * Patient who is scheduled to undergo primary major limb amputation with concurrent TMR Inclusion Criteria: Control Cohort * Patient with history of major limb amputation recruited from local clinics who has not been referred or seen for consultation for TMR by attending plastic surgeon at UW Exclusion Criteria: Study Cohort * Retrospective * Patient underwent TMR at another institution * Less than 6 months follow up * Less than 18 years of age * Enrolled in other studies relating to neuropathic pain * Undergoing radiation therapy * Incarcerated * Incomplete survey response * Non-English speaking (chosen PROMIS measures only in English) * Prospective * Less than 18 years of age * Cognitive impairment * Enrolled in other studies relating to neuropathic pain * Undergoing radiation therapy * Incarcerated * Non-English speaking (chosen PROMIS measures only in English) Exclusion Criteria: Control Cohort * Less than 18 years of age * Cognitive impairment * Enrolled in other studies relating to neuropathic pain * Undergoing radiation therapy * Incarcerated * Incomplete survey response * Major limb amputee seeking consultation for TMR * Non-English speaking (chosen PROMIS measures only in English)

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Amputation

Contacts and locations

Locations

  • University of Wisconsin

    Madison, Wisconsin, 53792, United States

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