Cure My Disease

Don't miss your cure!

 Log in / Sign up

Surgery aims to give amputees separate muscle signals for better prosthetic control

NCT ID NCT07831278

NEW Symptom relief Sponsor: Brigham and Women's Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 21, 2026 · Last updated Sep 21, 2026

Summary

Researchers at Brigham and Women's Hospital are testing a surgical technique that creates extra nerve interfaces, called regenerative peripheral nerve interfaces (RPNIs), during amputation or revision surgery. The goal is to let participants control different muscles independently, which could improve how they use a prosthetic limb. Ten adults aged 18 to 65 will have the modified procedure, then attend follow-up visits and use a wearable device at home for daily training tasks and games. The study measures how much the nerve signals interfere with each other and how well participants perform the training tasks.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
regenerative peripheral nerve interfaces (RPNIs) created during amputation or revision surgery
What this could lead to
If it works, this could give people with amputations more natural, independent control of a prosthetic limb and reduce unwanted muscle crosstalk.
What could go wrong
This is a very small, early study of a new surgical technique. The approach may not produce reliable muscle control, and surgery carries risks such as infection, pain, or poor wound healing.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 10 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2026

An estimate. Start dates often move.

Expected to finish

Aug 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 18-65 * Fluent in English * Approved for and scheduled to undergo acute amputation or revision amputation surgery (e.g. above-knee amputation with sciatic nerve ablation) OR sciatic nerve ablation for clinical indications (e.g. persistent pain, symptomatic neuroma, soft tissue breakdown, muscle atrophy, socket-related discomfort). * Willing and able to initiate participation within 14 days of surgery * Willing to perform at home studies * Possess adequate cognitive and communication abilities to describe their sensorimotor recovery during follow-up assessments * Demonstrate appropriate motivation and reliability to comply with scheduled training and evaluation sessions throughout the postoperative period * Able to travel to BWH/BWFH and Harvard University for all required visits without lodging support Exclusion Criteria: * • Passive or active metal implants incompatible with EMG * Pacemakers, deep brain stimulators, or other electronic implantables * Pregnancy or breastfeeding * Current seizure disorder or other neurologically limiting conditions * Cognitive or developmental disorders that limit task comprehension * Vascular disorders impeding regeneration * Known impairments in wound healing, including connective tissue disorders or under chronic systemic corticosteroid therapy * Extensive peripheral neuropathies that may hinder neural regeneration and functional RPNI development * Active smoker * Are unable to provide informed consent * Have a demonstrated history of poor protocol adherence * Pregnant at the time of screening

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Amputation are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

Phantom Limb

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Amputation

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    2 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Brigham and Women's Hospital

    RECRUITING

    Boston, Massachusetts, 02115, United States

  • Harvard University

    NOT_YET_RECRUITING

    Cambridge, Massachusetts, 02138, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.