Can a simple injection or a mild electric current ease jaw pain?
NCT ID NCT07802236
First seen Sep 03, 2026 · Last updated Sep 09, 2026 · Updated 2 times
Summary
This trial tests two treatments for a jaw joint condition called TMJ disc displacement with reduction, where the disc that cushions the joint slips out of place but returns to normal when the mouth opens. Researchers will compare injecting hyaluronic acid, a natural lubricant, against applying radiofrequency current, a procedure that uses heat to calm nerve activity. The study includes 30 adults with jaw pain lasting at least three months. The goal is to see which approach better reduces pain, improves how wide the mouth can open, and lessens jaw clicking.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Hyaluronic acid injection or radiofrequency current therapy
- What this could lead to
- If successful, this could identify a more effective, less invasive way to manage TMJ disc displacement, potentially reducing pain and improving jaw function without surgery.
- What could go wrong
- This is a small, early-stage trial with only 30 participants, so results may not apply broadly. Both treatments carry risks like infection or discomfort, and neither may prove clearly better than the other.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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30 people
The number who actually took part.
- Started
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Apr 2023
- Finished
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Feb 2024
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 60 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Adult patients over 18 years of age. 2. Patients were diagnosed with internal derangement of TMJ. (Anterior disc displacement with reduction) 3. TMJ pain of non-odontogenic origin as confirmed by Research Diagnostic Criteria (RDC) for TMD/RDC axis II. 4. Pain on chewing or maximal mouth opening with a duration of at least 3 months. 5. Patients were accepted study condition and agree to attend to schedule follow up. \- Exclusion Criteria: 1. Anterior disc displacement without reduction 2. Trauma cases 3. Polyarthritis as rheumatoid 4. Cases that had contraindication to perform MRI scan. 5. Cases that had contraindication to RF 1. Pregnancy 2. Presence of metal elements at area of therapy (plates and screws after osteosynthesis) 3. Tumors. 4. Skin diseases. 5. Open wounds. 6. Acute phase of thyroid diseases. 7. Muscular dystrophy. -
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Faculty of dental medicine , Al Azhar university
Asyut, Asyut Governorate, Egypt
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Other studies related to the condition(s) this trial covers.