New pill targets rare cancer gene in 60-Patient trial
NCT ID NCT06010342
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase 2 trial is testing a drug called TL118 in 60 adults with advanced solid tumors that have a specific genetic change called an NTRK gene fusion. The drug is taken by mouth and aims to shrink tumors or stop them from growing. The study is currently recruiting participants who have already tried other treatments.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- TL118 (a drug taken by mouth that targets tumors with a specific genetic change called NTRK fusion)
- What this could lead to
- If successful, this could provide a new treatment option for people with certain hard-to-treat cancers that have an NTRK gene fusion.
- What could go wrong
- This is a small, early-phase study with only 60 participants, so results may not apply to everyone. The drug may not shrink tumors or could cause side effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Adventist Health Glendale
RECRUITINGGlendale, California, 91206, United States
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Affiliated Cancer Hospital and Institute of Guangzhou Medical University
RECRUITINGGuangzhou, Guangdong, China
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Affiliated Cancer Hospital of Xinjiang Medical University
RECRUITINGÜrümqi, Xinjiang, China
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Beijing Cancer Hospital
RECRUITINGBeijing, Beijing Municipality, China
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Chongqing University Cancer Hospital
RECRUITINGChongqing, Chongqing Municipality, China
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Fujian Cancer Hospital
RECRUITINGFuzhou, Fujian, China
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Harbin medical university cancer hospital
RECRUITINGHarbin, Heilongjiang, China
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Hunan Cancer Hospital
RECRUITINGChangsha, Hunan, China
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Jiangxi Cancer Hospital
RECRUITINGNanchang, Jiangxi, China
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Jinan Central Hospital
RECRUITINGJinan, Shandong, China
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Peking University School and Hospital of Stomatology
RECRUITINGBeijing, Beijing Municipality, China
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Shanghai East Hospital
RECRUITINGShanghai, Shanghai Municipality, China
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Shanxi Cancer Hospital
RECRUITINGXi'an, Shaanxi, China
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Texas Oncology
RECRUITINGDallas, Texas, 75251, United States
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The First Affiliated Hospital of Zhengzhou University
RECRUITINGZhengzhou, Henan, China
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The University of Texas MD Anderson Cancer Center
RECRUITINGHouston, Texas, 77030, United States
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Union Hospital Tongji Medical College Huazhong University of Science and Technology
RECRUITINGWuhan, Hubei, China
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West China Hospital of Sichuan University
RECRUITINGChengdu, Sichuan, China
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Zhejiang Cancer Hospital
RECRUITINGHangzhou, Zhejiang, China
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