Brain scans reveal how anxiety drugs affect threat response in depressed patients

NCT ID NCT06004115

First seen Nov 01, 2025 · Last updated Jun 17, 2026 · Updated 39 times

Summary

This study looks at how the brain reacts to threats in people with depression, anxiety, or both. About 165 adults will take a single dose of an anti-anxiety drug or a placebo and then have their brain activity measured with MRI and eye-blink tests. The goal is to find differences in threat processing between these groups, which could help improve treatments for co-occurring depression and anxiety.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Laureate Institute for Brain Research

    RECRUITING

    Tulsa, Oklahoma, 74136, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

Conditions

The condition(s) this trial relates to.

anxiety disorder Depression depressive disorder major depressive disorder mixed anxiety and depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.