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Thigh muscle clues may predict who gets knee pain relief

NCT ID NCT07781059

Knowledge-focused Sponsor: Marmara University Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
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Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 24, 2026 · Last updated Aug 25, 2026 · Updated 1 time

Summary

This observational study explores whether thigh muscle structure can predict pain relief after a genicular nerve block, an injection that blocks pain signals from the knee, in people with chronic knee osteoarthritis. Researchers will measure thigh muscle thickness, fiber length, and angle using ultrasound before the procedure, then track pain, function, and quality of life for three months. The goal is to see if these muscle measurements are linked to how well the nerve block works, potentially helping doctors personalize treatment.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
genicular nerve block
What this could lead to
If thigh muscle structure predicts who benefits from a genicular nerve block, doctors could better select patients for this pain-relieving procedure, improving outcomes and avoiding ineffective injections.
What could go wrong
This is a small observational study, so it cannot prove cause and effect. The findings may not apply to all people with knee osteoarthritis, and the procedure itself carries risks like infection or nerve damage.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

41 people

The number who actually took part.

Started

Jun 2025

Finished

Apr 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Adults aged 50 to 80 years with unilateral chronic knee pain due to clinically and radiologically confirmed knee osteoarthritis. Participants had Kellgren-Lawrence grade 3 or 4 osteoarthritis, had not responded adequately to conservative treatments, and were already scheduled to undergo genicular nerve block as part of routine clinical care.

Ages

50 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age between 50 and 80 years * Unilateral symptomatic knee osteoarthritis * Chronic knee pain for at least 3 months * Clinical and radiographic confirmation of knee osteoarthritis * Kellgren-Lawrence grade 3 or 4 knee osteoarthritis * Inadequate clinical response despite analgesic therapy and physical therapy * Clinical indication for genicular nerve block Exclusion Criteria: * History of surgery involving the knee region * Bilateral symptomatic knee osteoarthritis * Intra-articular knee injection within the previous 3 months * Systemic disease that could affect study assessments * Systemic or local infection * Coagulation disorder * Failure to provide written informed consent

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Conditions

The condition(s) this trial relates to.

agnosia osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chronic knee pain Knee arthritis, osteoarthritis

Contacts and locations

Locations

  • Marmara University Pendik Training and Research Hospital

    Istanbul, Pendik, 34899, Turkey (Türkiye)

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