New vaccine combo aims to tame chronic hepatitis b

NCT ID NCT05770895

Completed Disease control Sponsor: Gilead Sciences Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This early-stage trial tested two experimental therapeutic vaccines, GS-2829 and GS-6779, in 83 healthy people and those with chronic hepatitis B. The main goal was to check safety and tolerability, while also measuring immune responses. The vaccines are designed to help the body fight the hepatitis B virus, potentially offering a new way to control the disease.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: GS-2829 and GS-6779 (therapeutic vaccines)
What this could lead to: If successful, this could point toward a new treatment option that helps control chronic hepatitis B without lifelong medication.
What could go wrong: This is an early Phase 1 trial focused on safety, so it is too soon to know if the vaccines will work. The study is small and may not show strong enough immune responses.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

chronic hepatitis B virus infection hepatitis B virus infection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC HEPATITIS B

Contacts and locations

Locations

Chang Gung Medical Foundation Kaohsiung Chang Gung Memorial Hospital

Kaohsiung City, 833, Taiwan
Chang Gung Medical Foundation Linkou Chang Gung Memorial Hospital

Taoyuan City, 33305, Taiwan
Chia-Yi Christian Hospital

Chiayi City, 60002, Taiwan
E-DA Hospital

Kaohsiung City, 82445, Taiwan
Kaohsiung Medical University Hospital

Kaohsiung City, 807, Taiwan
National Cheng Kung University Hospital

Tainan, 7428, Taiwan
National Taiwan University Hospital

Taipei, 100229, Taiwan
New Zealand Clinical Research (NZCR)

Auckland, 1010, New Zealand
St. Martin De Porres Hospital

Chiayi City, 600, Taiwan

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