Can a biologic drug help peanut allergy sufferers tolerate nuts?
NCT ID NCT07015996
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This Phase 2 trial tests whether adding tezepelumab (a biologic drug) to peanut oral immunotherapy (OIT) helps people with peanut allergy tolerate more peanut without symptoms. 62 participants aged 12 to 55 will first receive tezepelumab or placebo alone, then both groups undergo peanut OIT for 56 weeks, followed by a 12-week withdrawal period. The main goal is to see if participants can eat a cumulative dose of 4000 mg of peanut protein without symptoms after stopping all treatment.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
tezepelumab (a biologic drug) and peanut oral immunotherapy (gradual exposure to peanut protein)
What this could lead to
If successful, this could point toward a treatment that allows people with peanut allergy to safely eat small amounts of peanut without severe reactions.
What could go wrong
This is an early Phase 2 proof-of-concept trial with only 62 participants, so results may not apply to everyone. There is also a risk of allergic reactions during the oral immunotherapy phase.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Arkansas Children's Hospital Research Institute: Department of Pediatrics, Allergy & Immunology
NOT_YET_RECRUITINGLittle Rock, Arkansas, 72202, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Boston Children's Hospital: Allergy and Asthma Program
NOT_YET_RECRUITINGBoston, Massachusetts, 02115, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Cincinnati Children's Hospital Medical Center: Division of Allergy and Immunology
RECRUITINGCincinnati, Ohio, 45229, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Icahn School of Medicine at Mount Sinai: Department of Pediatrics Allergy & Immunology
NOT_YET_RECRUITINGNew York, New York, 10029-6574, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Johns Hopkins Children's Center: Department of Allergy & Immunology
NOT_YET_RECRUITINGBaltimore, Maryland, 21287, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Massachusetts General Hospital: Department of Medicine: Allergy & Clinical Immunology Unit
NOT_YET_RECRUITINGBoston, Massachusetts, 02114, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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North Carolina Children's Hospital: Department of Pediatrics, Division of Allergy, Immunology and Rheumatology
RECRUITINGChapel Hill, North Carolina, 27599, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The University of Michigan: Division of Allergy and Clinical Immunology
NOT_YET_RECRUITINGAnn Arbor, Michigan, 48105, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of California, Los Angeles: Department of Medicine, Division of Clinical Immunology and Allergy
NOT_YET_RECRUITINGLos Angeles, California, 90095, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Texas Southwestern Medical Center: Division of Allergy and Immunology
NOT_YET_RECRUITINGDallas, Texas, 75390-9063, United States