New drug aimed at Hard-to-Treat lung cancer enters Mid-Stage trial

NCT ID NCT06568939

Recruiting now Disease control Sponsor: AbbVie Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Aug 14, 2026 · Updated 7 times

Summary

This phase 2 trial is testing three different doses of an investigational drug called telisotuzumab vedotin in about 150 adults with a specific type of advanced lung cancer (non-small cell lung cancer that has high levels of a protein called c-Met and no EGFR mutation). The drug is designed to target and kill cancer cells while sparing healthy ones. Researchers will monitor safety, side effects, and whether the tumors shrink. The study is currently recruiting at sites worldwide.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Telisotuzumab vedotin (a drug that targets cancer cells with high c-Met protein)
What this could lead to: If successful, this could provide a new treatment option for people with a specific type of lung cancer that has not responded to prior therapy.
What could go wrong: This is an early-phase trial with only 150 participants, so results may not apply to everyone. The drug can cause side effects like lung inflammation, nerve damage, and eye problems.

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Conditions

The condition(s) this trial relates to.

non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NON-SMALL CELL LUNG CANCER

Contacts and locations

Locations

Affiliated Cancer Hospital of Guangxi Medical University /ID# 271931
RECRUITING

Nanning, Guangxi, 530021, China
Astera Cancer Care /ID# 272359
RECRUITING

East Brunswick, New Jersey, 08816-4096, United States
Beijing Chest Tumor Hospital /ID# 271935
RECRUITING

Beijing, Beijing Municipality, 101149, China
Cancer Care Associates Of York /ID# 270971
RECRUITING

York, Pennsylvania, 17403, United States
Cancer Hospital Affliated to Xinjiang Medical University /ID# 271933
RECRUITING

Ürümqi, Xinjiang, 830011, China
Cancer Specialists of North Florida - Jacksonville - AC Skinner Parkway /ID# 270899
RECRUITING

Jacksonville, Florida, 32256, United States
Cepen - Centro De Pesquisa E Ensino Em Oncologia De Santa Catarina /ID# 273204
RECRUITING

Florianópolis, Santa Catarina, 88020-210, Brazil
Clinical Hospital Center - Bezanijska Kosa /ID# 270558
RECRUITING

Belgrade, Beograd, 11080, Serbia
Clinical Research Alliance - Westbury /ID# 270455
RECRUITING

Westbury, New York, 11590, United States
Community Cancer Trials Of Utah /ID# 276598
RECRUITING

Ogden, Utah, 84405, United States
Comprehensive Hematology Oncology /ID# 270422
RECRUITING

St. Petersburg, Florida, 33701-4732, United States
FirstHealth of the Carolinas- Speciality Center /ID# 272924
RECRUITING

Pinehurst, North Carolina, 28374, United States
Florida Cancer Specialists - East /ID# 271993
RECRUITING

West Palm Beach, Florida, 33401, United States
Florida Cancer Specialists - North /ID# 271995
RECRUITING

St. Petersburg, Florida, 33705, United States
Fujian Province Cancer Hospital /ID# 276178
RECRUITING

Fuzhou, Fujian, 350014, China
Fujieda Municipal General Hospital /ID# 277025
RECRUITING

Fujieda, Shizuoka, 426-0077, Japan
Genesis Healthcare System /ID# 273361
RECRUITING

Zanesville, Ohio, 43701, United States
Guthrie Robert Packer Hospital /ID# 270316
RECRUITING

Sayre, Pennsylvania, 18840, United States
Harbin Medical University Cancer Hospital /ID# 271665
RECRUITING

Harbin, Heilongjiang, 150081, China
Henan Cancer Hospital /ID# 271927
RECRUITING

Zhengzhou, Henan, 450008, China
Hokkaido University Hospital /ID# 277014
RECRUITING

Sapporo, Hokkaido, 060-8648, Japan
Hospital Alemao Oswaldo Cruz - Sao Paulo /ID# 272512
RECRUITING

São Paulo, 01323-020, Brazil
Hospital De Cancer De Pernambuco /ID# 276104
RECRUITING

Recife, Pernambuco, 50040-000, Brazil
Ictrials Pesquisa E Desenvolvimento /ID# 276681
RECRUITING

Curitiba, Paraná, 80510-130, Brazil
Illinois Cancer Specialists /ID# 274678
RECRUITING

Niles, Illinois, 60714, United States
Institute For Pulmonary Diseases Of Vojvodina /ID# 270559
RECRUITING

Kamenitz, Sremski Okrug, 21208, Serbia
Institute for Oncology and Radiology of Serbia /ID# 270561
RECRUITING

Belgrade, Beograd, 11000, Serbia
Ironwood Cancer and Research Center /ID# 276370
RECRUITING

Chandler, Arizona, 85224, United States
Kaiser Permanente Moanalua Medical Center /ID# 272916
RECRUITING

Honolulu, Hawaii, 96819, United States
Kitasato University Hospital /ID# 277012
RECRUITING

Sagamihara-shi, Kanagawa, 252-0375, Japan
Kobe Minimally Invasive Cancer Center /ID# 277469
RECRUITING

Kobe, Hyōgo, 650-0046, Japan
Kurashiki Central Hospital /ID# 276995
RECRUITING

Kurashiki-shi, Okayama-ken, 710-8602, Japan
Liga Norte Riograndense Contra O Cancer /ID# 273183
RECRUITING

Natal, Rio Grande do Norte, 59075-740, Brazil
LinYi Cancer Hospital /ID# 272068
RECRUITING

Linyi, Shandong, 276001, China
Medical Oncology Associates - Spokane /ID# 277172
RECRUITING

Spokane, Washington, 99208, United States
Medical University of South Carolina /ID# 273272
RECRUITING

Charleston, South Carolina, 29425, United States
Meir Medical Center /ID# 270071
RECRUITING

Kefar Sava, Central District, 4428164, Israel
Memorial Hospital West /ID# 270313
RECRUITING

Pembroke Pines, Florida, 33028, United States
Memorial University Medical Center /ID# 272467
COMPLETED

Savannah, Georgia, 31404, United States
Mercy Health - Perrysburg Cancer Center /ID# 270536
RECRUITING

Perrysburg, Ohio, 43551, United States
Military Medical Academy /ID# 279873
RECRUITING

Belgrade, Beograd, 11000, Serbia
Montefiore Medical Center - Einstein Campus /ID# 277169
RECRUITING

The Bronx, New York, 10461, United States
Nagoya University Hospital /ID# 277010
RECRUITING

Nagoya, Aichi-ken, 466-8560, Japan
National Cancer Center Hospital East /ID# 277056
RECRUITING

Kashiwa-shi, Chiba, 277-8577, Japan
National Cancer Centre Singapore /ID# 271499
RECRUITING

Singapore, Central Singapore, 169611, Singapore
National University Hospital /ID# 271700
RECRUITING

Singapore, 119074, Singapore
Nebraska Cancer Specialists - Omaha - Wright Street /ID# 271527
RECRUITING

Omaha, Nebraska, 68130, United States
Nebraska Hematology-Oncology /ID# 272970
RECRUITING

Lincoln, Nebraska, 68506, United States
Northwest Georgia Oncology Centers /ID# 275374
RECRUITING

Marietta, Georgia, 30060, United States
Northwest Medical Specialties Tacoma /ID# 270534
RECRUITING

Tacoma, Washington, 98405, United States
Ocala Oncology Center /ID# 273697
RECRUITING

Ocala, Florida, 34474, United States
Oncosite - Centro de Pesquisa Clinica em Oncologia /ID# 272513
RECRUITING

Ijuí, Rio Grande do Sul, 98700-000, Brazil
Rabin Medical Center. /ID# 270087
RECRUITING

Petah Tikva, Central District, 4941492, Israel
Rambam Health Care Campus- Haifa /ID# 270078
RECRUITING

Haifa, 3109601, Israel
Regional Cancer Care Associates /ID# 270783
RECRUITING

Teaneck, New Jersey, 07666, United States
Renown Regional Medical Center /ID# 273535
RECRUITING

Reno, Nevada, 89502, United States
SCRI Oncology Partners /ID# 270162
RECRUITING

Nashville, Tennessee, 37203, United States
Saint Francis Cancer Center - Greenville /ID# 276368
RECRUITING

Greenville, South Carolina, 29607, United States
Sendai Kousei Hospital /ID# 277023
RECRUITING

Sendai, Miyagi, 981-0914, Japan
Shaare Zedek Medical Center /ID# 270095
COMPLETED

Jerusalem, 9103102, Israel
Springfield Clinic - First /ID# 272576
RECRUITING

Springfield, Illinois, 62702, United States
Suporte Nutricional e Quimioterapia LTDA - PRONUTRIR /ID# 273203
RECRUITING

Fortaleza, Ceará, 60810-180, Brazil
Texas Oncology - Dallas - Worth Street /ID# 278947
RECRUITING

Dallas, Texas, 75246, United States
Texas Oncology - Northeast Texas /ID# 272000
RECRUITING

Tyler, Texas, 75702, United States
The Chaim Sheba Medical Center /ID# 270068
RECRUITING

Ramat Gan, Tel Aviv, 5265601, Israel
The First Affiliated Hospital of Nanchang University /ID# 271666
RECRUITING

Nanchang, Jiangxi, 330006, China
The First Affiliated Hospital of Xi'an Jiaotong University /ID# 271928
RECRUITING

Xi'an, Shaanxi, 710061, China
Union Hospital - Tongji Medical College /ID# 271668
RECRUITING

Wuhan, Hubei, 430022, China
University Cancer & Blood Center /ID# 270969
RECRUITING

Athens, Georgia, 30607, United States
University Clinical Center Kragujevac /ID# 275773
RECRUITING

Kragujevac, Sumadijski Okrug, 34000, Serbia
University Clinical Center Nis /ID# 270557
RECRUITING

Niš, Nisavski Okrug, 18300, Serbia
University Clinical Center Serbia /ID# 270808
RECRUITING

Belgrade, Beograd, 11000, Serbia
University of Arkansas for Medical Sciences /ID# 272923
RECRUITING

Little Rock, Arkansas, 72205, United States
University of Illinois Hospital and Health Sciences System /ID# 275345
RECRUITING

Chicago, Illinois, 60607, United States
University of Miyazaki Hospital /ID# 277020
RECRUITING

Miyazaki, Miyazaki, 889-1692, Japan
University of Virginia /ID# 284472
WITHDRAWN

Charlottesville, Virginia, 22908, United States
Valkyrie Clinical Trials /ID# 271322
RECRUITING

Los Angeles, California, 90067, United States
Virginia Cancer Specialists - Fairfax /ID# 272004
RECRUITING

Fairfax, Virginia, 22031, United States
Wakayama Medical University Hospital /ID# 276997
RECRUITING

Wakayama, Wakayama, 641-8510, Japan
Yale New Haven Hospital /ID# 271584
RECRUITING

New Haven, Connecticut, 06510, United States

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