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New hope for lung cancer patients whose treatment has failed

NCT ID NCT07155187

Recruiting now Disease control Sponsor: AbbVie Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 10, 2026 · Updated 2 times

Summary

This study tests a new drug, telisotuzumab adizutecan, in people with advanced EGFR-mutated non-small cell lung cancer whose cancer has progressed after a third-generation targeted therapy. About 430 adults will receive either the new drug or standard care. The goal is to see if the new drug can shrink tumors or delay cancer growth better than current options.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
telisotuzumab adizutecan
What this could lead to
If it works, this could offer a new treatment option for people with a specific type of lung cancer that has stopped responding to current targeted therapies.
What could go wrong
This is an early-to-mid-stage trial, so the drug may not prove more effective than standard care. Side effects from the investigational drug are not yet fully known.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

neoplasm non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NON-SMALL CELL LUNG CANCER

Contacts and locations

Locations

  • AOU Policlinico G. Rodolico - San Marco /ID# 277265

    RECRUITING

    Catania, 95123, Italy

  • AST Pesaro Urbino - Presidio Ospedaliero Santa Croce Di Fano /ID# 277338

    RECRUITING

    Fano, Pesaro E Urbino, 61032, Italy

  • Adana Sehir Hastanesi /ID# 276957

    RECRUITING

    Adana, 01370, Turkey (Türkiye)

  • Ankara Universitesi Tip Fakultesi Cebeci Hastanesi /ID# 276961

    RECRUITING

    Ankara, 06620, Turkey (Türkiye)

  • Asan Medical Center /ID# 277371

    RECRUITING

    Seoul, Seoul Teugbyeolsi, 05505, South Korea

  • Astera Cancer Care /ID# 277570

    RECRUITING

    East Brunswick, New Jersey, 08816-4096, United States

  • Azienda Ospedaliera Universitaria Integrata Verona - Ospedale Borgo Trento /ID# 277280

    RECRUITING

    Verona, 37126, Italy

  • CHU Brest - Hopital de la Cavale Blanche /ID# 277883

    RECRUITING

    Brest, Finistere, 29200, France

  • CHU de Lille - Institut Coeur Poumon /ID# 276868

    RECRUITING

    Lille, Hauts-de-France, 59000, France

  • Canberra Hospital /ID# 277166

    RECRUITING

    Garran, Australian Capital Territory, 2605, Australia

  • Cancer Care Centers of Brevard- Rockledge /ID# 277853

    RECRUITING

    Rockledge, Florida, 32955, United States

  • Cancer Specialists of North Florida /ID# 277332

    RECRUITING

    Jacksonville, Florida, 32256, United States

  • Centro Di Riferimento Oncologico /ID# 276923

    RECRUITING

    Aviano, Pordenone, 33081, Italy

  • Changhua Christian Hospital /ID# 277145

    RECRUITING

    Changhua, 500, Taiwan

  • Chungbuk National University Hospital /ID# 277372

    RECRUITING

    Cheongju-si, North Chungcheong, 28644, South Korea

  • City of Hope - Orange County Lennar Foundation Cancer Center /ID# 277928

    RECRUITING

    Irvine, California, 92618, United States

  • City of Hope National Medical Center /ID# 277005

    RECRUITING

    Duarte, California, 91010, United States

  • Clinical Hospital Center - Bežanijska Kosa /ID# 277052

    RECRUITING

    Belgrade, Beograd, 11080, Serbia

  • Complejo Hospitalario Universitario de Santiago /ID# 277173

    RECRUITING

    Santiago de Compostela, A Coruna, 15706, Spain

  • Dartmouth-Hitchcock Medical Center /ID# 277673

    RECRUITING

    Lebanon, New Hampshire, 03756, United States

  • Erasmus Medisch Centrum /ID# 276989

    RECRUITING

    Rotterdam, South Holland, 3015 CE, Netherlands

  • Fred Hutchinson Cancer Center. /ID# 277939

    RECRUITING

    Seattle, Washington, 98109-4405, United States

  • Gazi University Medical Faculty /ID# 276943

    RECRUITING

    Ankara, 06560, Turkey (Türkiye)

  • Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi /ID# 276956

    RECRUITING

    Istanbul, 34722, Turkey (Türkiye)

  • Grand Hopital de Charleroi - Les Viviers /ID# 277282

    RECRUITING

    Charleroi, Hainaut, 6280, Belgium

  • Groupe Sante CHC - Clinique du MontLegia /ID# 278951

    RECRUITING

    Liège, Liege, 4000, Belgium

  • Guangdong Provincial People's Hospital /ID# 277631

    RECRUITING

    Guangzhou, Guangdong, 510080, China

  • Gyncentrum Sp. z o.o. /ID# 277522

    RECRUITING

    Sosnowiec, Silesian Voivodeship, 41-208, Poland

  • HealthPartners Cancer Research Center /ID# 277339

    RECRUITING

    Saint Louis Park, Minnesota, 55426, United States

  • Highlands Oncology Group - Springdale /ID# 277132

    RECRUITING

    Springdale, Arkansas, 72762, United States

  • Hokkaido University Hospital /ID# 277240

    RECRUITING

    Sapporo, Hokkaido, 060-8648, Japan

  • Hopital Arnaud de Villeneuve /ID# 276872

    RECRUITING

    Montpellier, Herault, 34090, France

  • Hospital Clinico Universitario Lozano Blesa /ID# 277154

    RECRUITING

    Zaragoza, 50009, Spain

  • Hospital Clinico Universitario de Valencia /ID# 277147

    RECRUITING

    Valencia, 46010, Spain

  • Hospital Cuf Porto /ID# 277225

    RECRUITING

    Porto, 4100-180, Portugal

  • Hospital Universitari Parc Tauli /ID# 277177

    RECRUITING

    Sabadell, Barcelona, 08208, Spain

  • Hospital Universitari Vall d Hebron /ID# 277156

    RECRUITING

    Barcelona, 08035, Spain

  • Hospital Universitario 12 de Octubre /ID# 277155

    RECRUITING

    Madrid, 28041, Spain

  • Hospital Universitario Ramon y Cajal /ID# 277153

    RECRUITING

    Madrid, 28034, Spain

  • Hospital Universitario Virgen de la Victoria /ID# 277159

    RECRUITING

    Málaga, 29010, Spain

  • IRCCS Istituti Fisioterapici Ospitalieri-Istituto Nazionale Tumori Regina Elena /ID# 277296

    RECRUITING

    Rome, Roma, 00144, Italy

  • Icon Cancer Centre Hobart /ID# 277549

    RECRUITING

    Hobart, Tasmania, 7000, Australia

  • Institut Curie /ID# 277623

    RECRUITING

    Paris, Île-de-France Region, 75248, France

  • Institut Jules Bordet /ID# 277283

    RECRUITING

    Anderlecht, Brussels Capital, 1070, Belgium

  • Institute For Pulmonary Diseases Of Vojvodina /ID# 277047

    RECRUITING

    Kamenitz, Sremski Okrug, 21208, Serbia

  • Istituto Europeo Di Oncologia /ID# 276788

    RECRUITING

    Milan, Milano, 20141, Italy

  • Istituto di Candiolo Fondazione del Piemonte per l'Oncologia IRCCS /ID# 277119

    RECRUITING

    Candiolo, Torino, 10060, Italy

  • Jessa Ziekenhuis - Campus Virga Jesse /ID# 277202

    RECRUITING

    Hasselt, Limburg, 3500, Belgium

  • Kaohsiung Chang Gung Memorial Hospital /ID# 277472

    RECRUITING

    Kaohsiung City, 833, Taiwan

  • Kaohsiung Medical University Chung-Ho Memorial Hospital /ID# 277138

    RECRUITING

    Kaohsiung City, 807, Taiwan

  • Kitasato University Hospital /ID# 277241

    RECRUITING

    Sagamihara-shi, Kanagawa, 252-0375, Japan

  • Klinik Floridsdorf /ID# 276679

    RECRUITING

    Vienna, State of Vienna, 1210, Austria

  • Leids Universitair Medisch Centrum /ID# 277270

    RECRUITING

    Leiden, South Holland, 2333 ZA, Netherlands

  • Linkou Chang Gung Memorial Hospital /ID# 277135

    RECRUITING

    Taoyuan City, 333, Taiwan

  • Mackay Memorial Hospital /ID# 277146

    RECRUITING

    Taipei, 104, Taiwan

  • Marmara Universitesi Pendik Egitim ve Arastirma Hastanesi /ID# 277063

    RECRUITING

    Istanbul, 34899, Turkey (Türkiye)

  • Mater Hospital Brisbane /ID# 276985

    RECRUITING

    South Brisbane, Queensland, 4101, Australia

  • Meir Medical Center /ID# 277289

    RECRUITING

    Kefar Sava, Central District, 4428164, Israel

  • Moffitt Cancer Center /ID# 276785

    RECRUITING

    Tampa, Florida, 33612, United States

  • National Cancer Center /ID# 277353

    RECRUITING

    Goyang-si, Gyeonggido, 10408, South Korea

  • National Cancer Center Hospital /ID# 277093

    RECRUITING

    Chuo-Ku, Tokyo, 104-0045, Japan

  • National Taiwan University Cancer Center (Ntucc) /ID# 277134

    RECRUITING

    Taipei, 106, Taiwan

  • Nho - Revive Research Institute /ID# 277569

    RECRUITING

    Lincoln, Nebraska, 68506, United States

  • Northwest Cancer Specialists - Vancouver /ID# 277855

    RECRUITING

    Vancouver, Washington, 98684, United States

  • One Clinical Research - Nedlands /ID# 277598

    RECRUITING

    Nedlands, Western Australia, 6009, Australia

  • Ospedale Isola Tiberina - Gemelli Isola /ID# 277117

    RECRUITING

    Rome, Roma, 00186, Italy

  • Parkview Research Center /ID# 277651

    RECRUITING

    Fort Wayne, Indiana, 46845, United States

  • Pratia MCM Krakow /ID# 277118

    RECRUITING

    Krakow, Lesser Poland Voivodeship, 30-727, Poland

  • Provita Centrum Medyczne /ID# 277494

    RECRUITING

    Warsaw, Masovian Voivodeship, 00-585, Poland

  • Rabin Medical Center /ID# 276748

    RECRUITING

    Petah Tikva, Central District, 4941492, Israel

  • Radboudumc /ID# 277639

    RECRUITING

    Nijmegen, Gelderland, 6525 GA, Netherlands

  • Rambam Health Care Campus- Haifa /ID# 276746

    RECRUITING

    Haifa, 3109601, Israel

  • SCRI Oncology Partners /ID# 276959

    RECRUITING

    Nashville, Tennessee, 37203, United States

  • Sakarya Universitesi Tip Fakultesi - Korucuk Kampusu /ID# 276962

    RECRUITING

    Adapazarı, Sakarya, 54290, Turkey (Türkiye)

  • Samsun Medical Park Hastanesi /ID# 277201

    RECRUITING

    Samsun, 55200, Turkey (Türkiye)

  • Samsung Medical Center /ID# 277600

    RECRUITING

    Seoul, Seoul Teugbyeolsi, 06351, South Korea

  • Seoul National University Hospital /ID# 277373

    RECRUITING

    Seoul, Seoul Teugbyeolsi, 03080, South Korea

  • Shanghai Pulmonary Hospital /ID# 277488

    RECRUITING

    Shanghai, Shanghai Municipality, 200433, China

  • St Bartholomews Hospital - Barts Health /ID# 277301

    RECRUITING

    London, Greater London, EC1A 7BE, United Kingdom

  • St George Hospital - Kogarah /ID# 277168

    RECRUITING

    Kogarah, New South Wales, 2217, Australia

  • St Vincent's Hospital Melbourne /ID# 277002

    RECRUITING

    Fitzroy, Victoria, 03065, Australia

  • Sunshine Hospital /ID# 276894

    RECRUITING

    St Albans, Victoria, 3021, Australia

  • Taichung Veterans General Hospital /ID# 277142

    RECRUITING

    Taichung, 407, Taiwan

  • Taipei Veterans General Hospital /ID# 277141

    RECRUITING

    Taipei, 112, Taiwan

  • Tennessee Cancer Specialists - Knoxville - Old Weisgarber Road /ID# 277891

    RECRUITING

    Knoxville, Tennessee, 37909, United States

  • The Chaim Sheba Medical Center /ID# 276745

    RECRUITING

    Ramat Gan, Tel Aviv, 5265601, Israel

  • The Christie NHS Foundation Trust - Christie Hospital /ID# 277304

    RECRUITING

    Manchester, M20 4BX, United Kingdom

  • The First affiliated hospital of Nanchang University (Xianghu campus) /ID# 277491

    RECRUITING

    Nanchang, Jiangxi, 330209, China

  • Unidade Local de Saude de Braga, EPE /ID# 277217

    RECRUITING

    Braga, 4710-243, Portugal

  • Unidade Local de Saude de Loures-Odivelas /ID# 277223

    RECRUITING

    Loures, Lisbon District, 2674-514, Portugal

  • Unidade Local de Saude de Matosinhos EPE /ID# 277228

    RECRUITING

    Senhora da Hora, Porto District, 4464-513, Portugal

  • Unidade Local de Saude de Santo Antonio /ID# 277216

    RECRUITING

    Porto, 4099-003, Portugal

  • Unidade Local de Saude do Alto Ave, EPE /ID# 277249

    RECRUITING

    Guimarães, Braga District, 4835-044, Portugal

  • Universitaetsklinikum Giessen und Marburg GmbH /ID# 276873

    RECRUITING

    Marburg, Hesse, 35043, Germany

  • Universitaetsklinikum Hamburg-Eppendorf /ID# 276869

    RECRUITING

    Hamburg, 20246, Germany

  • Universitaetsklinikum Heidelberg /ID# 277275

    RECRUITING

    Heidelberg, Baden-Wurttemberg, 69120, Germany

  • Universitaetsklinikum Koeln /ID# 276862

    RECRUITING

    Cologne, North Rhine-Westphalia, 50937, Germany

  • Universitaetsklinikum Wuerzburg /ID# 277213

    RECRUITING

    Würzburg, Bavaria, 97080, Germany

  • Universitair Medisch Centrum Utrecht /ID# 277114

    RECRUITING

    Utrecht, 3584 CX, Netherlands

  • Universitair Ziekenhuis Leuven /ID# 276874

    RECRUITING

    Leuven, Vlaams-Brabant, 3000, Belgium

  • University Clinical Center Kragujevac /ID# 277162

    RECRUITING

    Kragujevac, Sumadijski Okrug, 34000, Serbia

  • University Clinical Center Nis /ID# 277200

    RECRUITING

    Niš, Nisavski Okrug, 18300, Serbia

  • University Clinical Center Serbia /ID# 277051

    RECRUITING

    Belgrade, Beograd, 11000, Serbia

  • Universitätsklinikum Jena /ID# 277281

    RECRUITING

    Jena, Thuringia, 07747, Germany

  • Uniwersyteckie Centrum Kliniczne /ID# 277210

    RECRUITING

    Gdansk, Pomeranian Voivodeship, 80-214, Poland

  • Wakayama Medical University Hospital /ID# 277238

    RECRUITING

    Wakayama, Wakayama, 641-8510, Japan

  • Wielkopolskie Centrum Pulmonologii i Torakochirurgii im. Eugenii i Janusza Zeyla /ID# 277066

    RECRUITING

    Poznan, Greater Poland Voivodeship, 60-569, Poland

  • Xinjiang Medical University Cancer Hospital - Urumqi /ID# 277638

    RECRUITING

    Ürümqi, Xinjiang, 830000, China

  • Yitzhak Shamir Medical Center /ID# 276750

    RECRUITING

    Ẕerifin, Central District, 7030000, Israel

  • Yonsei University Health System Severance Hospital /ID# 277394

    RECRUITING

    Seoul, Seoul Teugbyeolsi, 03722, South Korea

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