New drug combo shows promise in shrinking rectal tumors before surgery

NCT ID NCT04104139

First seen Oct 31, 2025 · Last updated May 23, 2026 · Updated 40 times

Summary

This early-stage study tests the safety of combining the chemotherapy drug TAS-102 with radiation therapy for people with stage II or III rectal cancer that hasn't been treated yet. The goal is to find the safest dose of TAS-102 to use with radiation before surgery. About 19 adults will take part, and researchers will monitor for side effects.

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Contacts and locations

Locations

  • OHSU Knight Cancer Institute

    Portland, Oregon, 97239, United States

Conditions

Explore the condition pages connected to this study.