STAGE III RECTAL CANCER AJCC V8
Clinical trials for STAGE III RECTAL CANCER AJCC V8 explained in plain language.
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New combo aims to spare rectal cancer patients from surgery
Disease control Recruiting nowThis phase II trial tests whether giving a combination of chemotherapy (FOLFOX) and two immunotherapy drugs (botensilimab and balstilimab) before surgery can eliminate rectal cancer without the need for surgery or radiation. The study includes adults with stage II or III rectal c…
Matched conditions: STAGE III RECTAL CANCER AJCC V8
Phase: PHASE2 • Sponsor: City of Hope Medical Center • Aim: Disease control
Last updated Jul 01, 2026 00:00 UTC
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Rectal cancer patients may skip surgery with chemo and watchful waiting
Disease control Recruiting nowThis early-phase trial is testing whether people with stage II-III rectal cancer can safely avoid surgery by first receiving chemotherapy and then being closely monitored. The goal is to see if the rectum can be preserved without harming survival. Around 120 participants will be …
Matched conditions: STAGE III RECTAL CANCER AJCC V8
Phase: EARLY_PHASE1 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated Jun 27, 2026 12:36 UTC
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New antibody shows promise in shrinking HER2+ colorectal tumors before surgery
Disease control Recruiting nowThis phase II trial tests whether giving zanidatamab before surgery can shrink tumors in people with HER2+ colorectal cancer. About 38 participants will receive the drug intravenously, then undergo surgery. The study measures how much the tumor regresses and whether cancer return…
Matched conditions: STAGE III RECTAL CANCER AJCC V8
Phase: PHASE2 • Sponsor: Emory University • Aim: Disease control
Last updated Jun 27, 2026 12:09 UTC
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New combo therapy aims to save rectums from surgery
Disease control Recruiting nowThis early-phase trial tests whether a short course of radiation followed by chemotherapy can shrink advanced rectal tumors enough to avoid surgery. About 25 people with stage II or III rectal cancer will receive the treatment. The goal is to preserve the rectum and improve quali…
Matched conditions: STAGE III RECTAL CANCER AJCC V8
Phase: PHASE1 • Sponsor: Jonsson Comprehensive Cancer Center • Aim: Disease control
Last updated Jun 27, 2026 12:01 UTC
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Who should tell relatives about cancer risk? new study tests best approach
Knowledge-focused Recruiting nowThis study looks at whether having a healthcare provider directly contact close relatives of people with newly diagnosed colorectal cancer leads to more genetic testing than having the patient share the information themselves. About 4,186 patients and their relatives will take pa…
Matched conditions: STAGE III RECTAL CANCER AJCC V8
Phase: NA • Sponsor: Alliance for Clinical Trials in Oncology • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:00 UTC
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New app aims to help cancer survivors and families stick to healthy habits
Knowledge-focused Recruiting nowThis study is creating and testing a mobile health app designed to help colorectal cancer survivors and their family caregivers follow healthy lifestyle recommendations. Researchers will work with 70 participants to see if the app is easy to use and acceptable. The goal is to imp…
Matched conditions: STAGE III RECTAL CANCER AJCC V8
Phase: NA • Sponsor: Ohio State University Comprehensive Cancer Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:05 UTC
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New study tracks life after rectal cancer surgery
Knowledge-focused Recruiting nowThis study follows 430 people with stage I-IV rectal cancer to measure their quality of life after surgery. Participants fill out questionnaires about their well-being and daily function. The goal is to learn how surgery impacts patients over time, not to test a new treatment.
Matched conditions: STAGE III RECTAL CANCER AJCC V8
Sponsor: M.D. Anderson Cancer Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:04 UTC
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Blood test may predict which rectal cancer patients can skip surgery
Knowledge-focused Recruiting nowThis study looks at whether a simple blood test can help doctors decide if rectal cancer patients can avoid surgery and keep their rectum. Researchers will measure tiny bits of tumor DNA in the blood (ctDNA) before, during, and after standard treatment. The goal is to see if chan…
Matched conditions: STAGE III RECTAL CANCER AJCC V8
Sponsor: OHSU Knight Cancer Institute • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:52 UTC