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Nerve block before or after surgery: which timing better blocks pain?

NCT ID NCT07809009

Symptom relief Sponsor: Pusan National University Yangsan Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 09, 2026 · Last updated Sep 10, 2026 · Updated 1 time

Summary

Researchers compare two timings for a nerve block given during laparoscopic gallbladder removal. One group receives the block before the surgical cut, the other after the wound is closed. Both groups get the same drug, ropivacaine, injected into the abdominal wall. The trial measures pain signals during surgery and pain scores, painkiller use, and complications afterward to see which timing works better.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
ropivacaine nerve block (transversus abdominis plane block)
What this could lead to
If the earlier block works better, it could give surgeons a simple way to reduce pain during and after gallbladder surgery. That might mean less opioid painkiller needed afterward.
What could go wrong
This is a small study in one type of surgery, so the results may not apply to other operations or patients. Nerve blocks carry small risks like bleeding or infection, and pain relief may not differ much between the two timings.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 120 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Aug 2026

An estimate. Start dates often move.

Expected to finish

Jun 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

19 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients scheduled to undergo laparoscopic cholecystectomy. * Aged 19 years or older. * American Society of Anesthesiologists (ASA) physical status I, II, or III. Exclusion Criteria: * Patients who lack the capacity to understand the study examinations or perform the assessment procedures. * Patients with coagulation deficiencies or bleeding disorders. * Patients with cardiac arrhythmias or those with an implanted cardiac pacemaker. * Patients taking medications that affect the autonomic nervous system, including beta-blockers and opioid analgesics. * Patients with surgical scars, active lesions, or anatomical abnormalities at the block site. * Patients with pre-existing neurological deficits or impairment at the block site. * Patients with a known history of allergic reactions or hypersensitivity to ropivacaine or other local anesthetics. * Pregnant or lactating individuals.

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Conditions

The condition(s) this trial relates to.

Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Laparoscopic cholecystectomy Postoperative pain

How to take part

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  1. The official record

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