Which lung cancer surgery cuts tumor DNA best? new trial aims to find out.
NCT ID NCT05502523
First seen Jan 29, 2026
Summary
This study compares two standard surgical techniques for removing early-stage lung cancer: tying off the pulmonary vein first versus the pulmonary artery first. Researchers want to see which method better reduces circulating tumor DNA (ctDNA) in the blood after surgery, which may be linked to lower risk of cancer spread. About 100 adults with stage I-III non-small cell lung cancer will participate, and blood samples will be taken before and after surgery to measure ctDNA levels.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Abington Memorial Hospital
RECRUITINGAbington, Pennsylvania, 19001, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Asplundh Cancer Pavilion at Jefferson Health
RECRUITINGWillow Grove, Pennsylvania, 19090, United States
Contact Phone: •••-•••-••••
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Jefferson Health Northeast
RECRUITINGPhiladelphia, Pennsylvania, 19107, United States
Contact Phone: •••-•••-••••
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Thomas Jefferson University Hospital
RECRUITINGPhiladelphia, Pennsylvania, 19107, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Pulmonary artery-first surgical technique
What this could lead to
If successful, this study could show that a specific surgical approach reduces cancer cells in the blood, potentially improving long-term survival for early-stage lung cancer patients.
What could go wrong
This is an early-stage observational study with only 100 participants, so results may not apply to all patients. The main goal is to measure tumor DNA, not directly prove better survival or cure.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.