Sugar-Digesting enzyme trial for short gut patients ends early
NCT ID NCT04604275
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested whether giving sucrase, an enzyme that breaks down sugar, could help people with short bowel syndrome and intestinal failure digest sugar better. The goal was to reduce symptoms like bloating, pain, and diarrhea, and help them tolerate more food. However, the trial was terminated early and only enrolled 3 participants, so the results are very limited.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
sucrase (an enzyme that helps digest sugar)
What this could lead to
If it works, this could help short bowel syndrome patients tolerate more food by mouth or feeding tube, reducing uncomfortable symptoms like bloating and diarrhea.
What could go wrong
This was a very small, early-phase trial that was terminated after enrolling only 3 people, so we have very little data. It is unclear if the enzyme is effective or safe in this group.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Jackson Memorial Hospital
Miami, Florida, 33136, United States
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University of Miami
Miami, Florida, 33136, United States