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Stress fingerprints: could blood tests forecast trauma aftermath?

NCT ID NCT04530214

Knowledge-focused Sponsor: Direction Centrale du Service de Santé des Armées Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 08, 2026 · Last updated Sep 09, 2026 · Updated 1 time

Summary

This study investigates whether the body's stress response after a severe physical trauma, such as a hip fracture, can predict long-term psychological and physical outcomes. Researchers will collect blood, saliva, and heart rate data from 20 older adults to look for biomarkers linked to stress and inflammation. Participants will also complete questionnaires about their mental health. The goal is to understand why some people develop depression or other after-effects following trauma, potentially leading to early identification and intervention.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Blood and saliva collection, electrocardiography, and questionnaires
What this could lead to
If successful, this could identify biomarkers that predict who will develop depression or other after-effects after severe trauma, enabling earlier support.
What could go wrong
This is a small observational study with only 20 participants, so findings may not apply broadly. The outcomes are exploratory and require confirmation in larger studies.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

20 people

The number who actually took part.

Started

Nov 2020

Finished

Apr 2023

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients admitted to the emergency room for a fracture of the upper end of the femur.

Ages

70 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Fracture of the upper end of the femur * Cognitive state allowing the understanding of questionnaires Exclusion Criteria: * Traumatic Brain Injury * Chronic inflammatory or immune pathologies * On anticoagulants * On neuroleptic or antidepressant treatment * Pathology or health condition not allowing 1-year survival

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Conditions

The condition(s) this trial relates to.

Fractures, Stress

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Stress reaction

Contacts and locations

Locations

  • CHU Pellegrin

    Bordeaux, 33000, France

  • Hôpital d'Instruction des Armées Bégin

    Saint-Mandé, 94163, France

  • Hôpital d'Instruction des Armées Percy

    Clamart, 92140, France

  • Hôpital d'Instruction des Armées Sainte-Anne

    Toulon, 83800, France

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