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Can a neck nerve block calm the Body's inflammatory storm after heart surgery?

NCT ID NCT07776496

Disease control Sponsor: OMAR ABDELAZIZ ABOELFADL Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 20, 2026 · Last updated Aug 21, 2026 · Updated 1 time

Summary

This trial tests whether an ultrasound-guided injection near a nerve cluster in the neck, called a left stellate ganglion block, can reduce inflammation and lower the risk of delirium in older adults undergoing coronary artery bypass graft (CABG) surgery. Half of the 81 participants will receive the block before anesthesia, while the other half will receive standard care. Researchers will measure changes in an inflammatory marker called IL-6 and track how many patients develop postoperative confusion.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
ultrasound-guided left stellate ganglion block with bupivacaine
What this could lead to
If effective, this nerve block could become a simple way to lower harmful inflammation and reduce confusion after heart surgery in older adults.
What could go wrong
This is a small, early-stage trial, and the block may not significantly reduce inflammation or delirium. There are also risks from the procedure itself, such as nerve injury or bleeding.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 81 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Dec 2026

An estimate. Start dates often move.

Expected to finish

Aug 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

65 to 85 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. All elderly (≥65 years) patients of both genders, as according to the World Health Organization, the chronologic age of 65 years was accepted by most developed countries in the world as a definition of "elderly" or older person. Patients scheduled for elective cardiac surgery under general anesthesia.14 2. American Society of Anesthesiologists (ASA) physical status class II or III. 3. Patients will be stratified according to their baseline surgical risk utilizing the EuroSCORE II tool \>4%15. 4. American Society of Anesthesiologists (ASA) physical status class II or III. Exclusion Criteria: 1. Pre-existing dementia or significant cognitive impairment. 2. History of stroke or cerebrovascular disease. 3. Contraindications to SGB (e.g., coagulopathy, local infection, or anatomical abnormalities). 4. Preoperative use of antipsychotics or antidepressants. 5. Sinus bradycardia \<50bpm \&complete heart block 6. BMI\>35 7. Redo or emergency surgery. 8. On preoperative mechanical ventilation and long sedation time. 9. Low EF patients \<35%.

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Conditions

The condition(s) this trial relates to.

coronary artery disorder Emergence Delirium

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CABG Delirium - postoperative Inflammation biomarkers Stellate ganglion block

How to take part

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  1. The official record

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