Landmark HIV study finds Heart-Protecting pill cuts major cardiac events

NCT ID NCT02344290

Completed Prevention Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) Source: ClinicalTrials.gov ↗

Summary

This large, international study aimed to see if a daily cholesterol-lowering pill (pitavastatin) could prevent heart attacks, strokes, and other major heart-related problems in adults living with HIV. Over 7,700 participants on stable HIV treatment, who had a low-to-moderate risk for heart disease, were randomly assigned to take either the drug or a placebo for several years. The trial was stopped early because the drug was found to be effective at reducing the risk of these serious cardiovascular events.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Contacts and locations

Show contact details

Locations

550 Clinic -University of Louisville CRS

Louisville, Kentucky, 40202, United States
AHF - South Beach CRS

Miami, Florida, 33140, United States
AHF-The Kinder Medical Group CRS

Miami, Florida, 33133, United States
AIDS Research and Treatment Center of the Treasure Coast CRS

Vero Beach, Florida, 32960, United States
Abbott Northwestern Hospital CRS

Minneapolis, Minnesota, 55407, United States
Alabama CRS*

Birmingham, Alabama, 35294, United States
Augusta University Research Institute, Inc. CRS

Augusta, Georgia, 30912, United States
Barranco CRS

Lima, 15063, Peru
Baystate Infectious Diseases Clinical Research CRS

Springfield, Massachusetts, 01199, United States
Bluegrass Care Clinic/University of Kentucky Research Foundation CRS

Lexington, Kentucky, 40536, United States
Boston Medical Center CRS

Boston, Massachusetts, 02118, United States
Brigham and Women's Hospital Therapeutics Clinical Research Site (BWH TCRS) CRS*

Boston, Massachusetts, 02115, United States
Byramjee Jeejeebhoy Medical College (BJMC) CRS

Pune, Maharashtra, 411001, India
Capital Medical Associates, PC CRS

Washington D.C., District of Columbia, 20036, United States
Case Clinical Research Site*

Cleveland, Ohio, 44106, United States
Center of Translational AIDS Research, Lewis Katz School of Medicine at Temple University CRS

Philadelphia, Pennsylvania, 19140, United States
Centre hospitalier de l'Université Laval CRS

Québec, Quebec, G1V 4G2, Canada
Centro de Pesquisas Clínicas IC-HCFMUSP CRS

São Paulo, 05403-010, Brazil
Centro de Referencia e Treinamento DST/AIDS CRS

São Paulo, São Paulo, 04121-000, Brazil
Chapel Hill CRS*

Chapel Hill, North Carolina, 27599, United States
Chennai Antiviral Research and Treatment (CART) CRS

Chennai, Tamil Nadu, 600113, India
Chiang Mai University HIV Treatment (CMU HIV Treatment) CRS

Chiang Mai, 50200, Thailand
Chronic Viral Illness Service CRS

Montreal, Quebec, H4A 3J1, Canada
Cincinnati Clinical Research Site*

Cincinnati, Ohio, 45219, United States
Columbia P&S CRS*

New York, New York, 10032-3732, United States
Community AIDS Network/Comprehensive Care Clinic CRS

Sarasota, Florida, 34237, United States
Cooper Univ. Hosp. CRS

Camden, New Jersey, 08103, United States
Dallas VA Medical Center CRS

Dallas, Texas, 75216, United States
Denver Public Health CRS

Denver, Colorado, 80204, United States
Department of Internal Medicine, University of Iowa Hospitals & Clinics CRS

Iowa City, Iowa, 52242, United States
Division of Infectious Diseases Clinical Research Center- Drexel University CRS

Philadelphia, Pennsylvania, 19102, United States
Duke University Medical Center CRS

Durham, North Carolina, 27710, United States
Durban International Clinical Research Site CRS

Durban, KwaZulu-Natal, 4052, South Africa
Eisenhower Health Center at Rimrock CRS

Palm Springs, California, 92264, United States
Famcru Crs

Tygerberg, Western Cape, 7505, South Africa
Florida Department of Health - Hillsborough County

Tampa, Florida, 33602, United States
GHESKIO Institute of Infectious Diseases and Reproductive Health (GHESKIO - IMIS) CRS

Port-au-Prince, HT-6110, Haiti
Gaborone CRS

Gaborone, South-East District, Botswana
Georgetown University CRS (GU CRS)

Washington D.C., District of Columbia, 20007, United States
Greensboro CRS*

Greensboro, North Carolina, 27401, United States
HGNI HIV Family Care Clinic - HHFCC CRS

Nova Iguaçu, Rio de Janeiro, 26030-380, Brazil
Hamilton Health Sciences - Special Immunology Services Clinic CRS

Hamilton, Ontario, L8S 1A4, Canada
Harbor-UCLA CRS*

Torrance, California, 90502, United States
Henry Ford Hosp. CRS

Detroit, Michigan, 48202, United States
Hospital Clinic de Barcelona

Barcelona, 08036, Spain
Hospital Federal dos Servidores do Estado CRS

Rio de Janeiro, 20221-903, Brazil
Hospital General Universitario De Elche

Elche, 03203, Spain
Hospital General Universitario de Alicante

Alicante, 03010, Spain
Hospital Germans Trias i Pujol

Badalona, 080916, Spain
Hospital Gregorio Universitario Maranon

Madrid, 28007, Spain
Hospital Nossa Senhora da Conceicao CRS

Porto Alegre, Rio Grande do Sul, 91350-200, Brazil
Hospital Universitario 12 de Octubre

Madrid, 28041, Spain
Hospital Universitario Clinico San Carlos

Madrid, 28040, Spain
Hospital Universitario La Paz

Madrid, 28046, Spain
Hospital Universitario Ramon y Cajal

Madrid, 28034, Spain
Hospital Universitario Valle d'Hebron

Barcelona, 08003, Spain
Hospital Universitario Virgen de la Victoria

Málaga, 29010, Spain
Hospital Universitario de Basurto de Basurto

Bilbao, 48013, Spain
Hospital Universitario de Bellvitge

Barcelona, 08907, Spain
Houston AIDS Research Team CRS*

Houston, Texas, 77030, United States
Indiana University Infectious Diseases Research CRS

Indianapolis, Indiana, 46202, United States
Infectious Disease Clinical and Translational Research Center (CTRC) CRS

New York, New York, 10029, United States
Infectious Diseases Clinic, Washington DC Veterans Affairs Medical Center CRS

Washington D.C., District of Columbia, 20422, United States
Inova Heart and Vascular Institute CRS

Falls Church, Virginia, 22042, United States
Instituto de Infectologia Emilio Ribas CRS

São Paulo, 01246-900, Brazil
Instituto de Pesquisa Clinica Evandro Chagas (IPEC) CRS

Rio de Janeiro, 21040-360, Brazil
James J Peters VA Medical Center CRS

The Bronx, New York, 10468, United States
Johns Hopkins University CRS*

Baltimore, Maryland, 21205, United States
Joint Clinical Research Centre (JCRC)/Kampala Clinical Research Site

Kampala, Uganda
Les Centres GHESKIO Clinical Research Site (GHESKIO-INLR) CRS

Port-au-Prince, HT-6110, Haiti
Los Angeles LGBT Center CRS

Los Angeles, California, 90232, United States
Malcom Randall VA Medical Center CRS

Gainesville, Florida, 32610, United States
Maple Leaf Research CRS

Toronto, Ontario, M5G 1K2, Canada
Massachusetts General Hospital CRS (MGH CRS)*

Boston, Massachusetts, 02114, United States
Medical College of Wisconsin, Inc. CRS

Milwaukee, Wisconsin, 53226, United States
Medical University of South Carolina: Division of Infectious Diseases CRS

Charleston, South Carolina, 29425, United States
Michael E. DeBakey VAMC REPRIEVE CRS

Houston, Texas, 77030, United States
Mills Clinical Research CRS

Los Angeles, California, 90069, United States
Milton Park CRS

Harare, Zimbabwe
Mount Sinai Beth Israel CRS*

New York, New York, 10003, United States
Mount Sinai Downtown CRS*

New York, New York, 10011, United States
Mount Sinai St. Luke's Morningside CRS*

New York, New York, 10025, United States
Mount Sinai West Samuels CRS*

New York, New York, 10019, United States
New Jersey Medical School Clinical Research Center CRS*

Newark, New Jersey, 07103, United States
Northwestern University CRS*

Chicago, Illinois, 60611, United States
Ohio State University CRS*

Columbus, Ohio, 43210, United States
Oklahoma State University Center for Health Sciences CRS

Tulsa, Oklahoma, 74127, United States
Orlando Immunology Center CRS

Orlando, Florida, 32803, United States
Penn Therapeutics, CRS*

Philadelphia, Pennsylvania, 19104, United States
Positive Health Clinic CRS

Pittsburgh, Pennsylvania, 15212, United States
Prisma Health CRS

Columbia, South Carolina, 29209, United States
Projeto Praça Onze Pesquisa em Saúde CRS

Rio de Janeiro, 20020-000, Brazil
Puerto Rico AIDS Clinical Trials Unit CRS*

San Juan, PR, 00935, Puerto Rico
Rush University CRS*

Chicago, Illinois, 60612, United States
San Miguel CRS

Lima, 32 - 15088, Peru
School of Medicine, Federal University of Minas Gerais CRS

Belo Horizonte, Minas Gerais, 30130-100, Brazil
Soweto ACTG CRS

Johannesburg, Gauteng, 1862, South Africa
Specialty Care Center CRS

Omaha, Nebraska, 68106, United States
St. John Newland Medical Associates CRS

Southfield, Michigan, 48075, United States
Stanford AIDS Clinical Trials Unit CRS

Palo Alto, California, 94304-5350, United States
Thai Red Cross AIDS Research Centre (TRC-ARC) CRS

Bangkok, 10330, Thailand
The Miriam Hospital Clinical Research Site (TMH CRS) CRS*

Providence, Rhode Island, 02906, United States
The Ponce de Leon Center CRS

Atlanta, Georgia, 30308-2012, United States
The University of Miami AIDS Clinical Research Unit (ACRU) CRS

Miami, Florida, 33136, United States
Toronto General Hospital CRS

Toronto, Ontario, M5G 2N2, Canada
Trinity Health and Wellness Center CRS

Dallas, Texas, 75208, United States
Tropical Medicine Foundation Dr. Heitor Vieira Dourado CRS

Manaus, Amazonas, 69040000, Brazil
Tufts Medical Center CRS

Boston, Massachusetts, 02111, United States
Tulane - Louisiana Community AIDS Research Program (T-LaCARP) CRS

New Orleans, Louisiana, 70112, United States
UCLA CARE Center CRS*

Los Angeles, California, 90035, United States
UCSD Antiviral Research Center CRS*

San Diego, California, 92103, United States
UIC Project WISH CRS

Chicago, Illinois, 60612, United States
UT Southwestern HIV/ID Clinical Trials Unit CRS

Dallas, Texas, 75235-9173, United States
Ucsf Hiv/Aids Crs*

San Francisco, California, 94110, United States
University of Arizona CRS

Tucson, Arizona, 85724, United States
University of Cape Town Lung Institute (UCTLI) CRS

Cape Town, Western Cape, 7700, South Africa
University of Colorado Hospital CRS*

Aurora, Colorado, 80045, United States
University of Miami Infectious Disease Research Unit at Jackson Memorial Hospital CRS

Miami, Florida, 33136, United States
University of Mississippi Medical Center CRS

Jackson, Mississippi, 39213, United States
University of Pittsburgh CRS*

Pittsburgh, Pennsylvania, 15213, United States
University of Rochester Adult HIV Therapeutic Strategies Network CRS*

Rochester, New York, 14642, United States
University of Southern California CRS*

Los Angeles, California, 90033-1079, United States
University of Toledo Medical Center CRS

Toledo, Ohio, 43614, United States
University of Washington AIDS CRS*

Seattle, Washington, 98104-9929, United States
VA Connecticut Healthcare System CRS

West Haven, Connecticut, 06516, United States
VA New York Harbor Healthcare System (NYHHS), NY Campus CRS

New York, New York, 10010, United States
VA West Los Angeles Medical Center CRS

Los Angeles, California, 90073, United States
Vancouver ID Research & Care Centre Society CRS

Vancouver, British Columbia, V6Z 2C7, Canada
Vanderbilt Therapeutics (VT) CRS*

Nashville, Tennessee, 37204, United States
Virginia Commonwealth University CRS

Richmond, Virginia, 23298, United States
Wake Forest Baptist Medical Center CRS

Winston-Salem, North Carolina, 27157, United States
Washington University Therapeutics (WT) CRS*

St Louis, Missouri, 63110-1010, United States
Weill Cornell Chelsea CRS*

New York, New York, 10010, United States
Weill Cornell Uptown CRS*

New York, New York, 10065, United States
Whitman-Walker Health CRS

Washington D.C., District of Columbia, 20005, United States
Wits Helen Joseph Hospital CRS (Wits HJH CRS)

Johannesburg, Gauteng, 2092, South Africa
Yale University CRS

New Haven, Connecticut, 06510, United States

Conditions

Explore the condition pages connected to this study.

CARDIOVASCULAR DISEASES HIV