Blood pressure drug takes on antibiotics for Women's acne

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patient with acne, with at least 10 inflammatory lesions and no more than 3 nodules * Patient who already had one cycline course for her acne treatment with a 3 months\* wash out or who never had any cycline * Patient having signed an informed consent * Absence of use of oral antibiotics and Zinc salts in the last 30 days * Absence of use of systemic isotretinoin and antiandrogens in the last 6 months * Absence of microphysiotherapy in the last 15 da * Women of child-bearing age under contraception since 3 months (oral contraception, implant or IUD). * Patients with social security Exclusion Criteria: * Patient affected by active /progressive diseases, as infections including Hidradenitis suppurativa, cancers, or endocrine syndrome (eg polycystic ovary syndrome), Addison's disease) * Patient affected by Rosacea * Patient with contra-indication to the use of one of the investigational products or auxiliary : * Patient with intolerance or hypersensitivity to cyclin's, spironolactone or to any ingredient present in associated benzoyl peroxide gel * Patient with significant impairment of renal excretory function, acute or chronic renal failure, anuria. * Patient with life-threatening or very severe hepatic impairment.(grade III or IV) * Patient with hyperkalaemia or strongly requiring potassium-sparing diuretics (eg amiloride, canrenoate, eplerenone, triamterene), or treated continuously with Angiotensin-converting-enzyme (ACE) inhibitors, angiotensin II antagonist, NSAIDs, heparin and molecular weight heparin, ciclosporin and tacrolimus. * Patient requiring topical isotretinoin or who stopped this drug since less than 2 weeks * Patient previously treated with spironolactone * Pregnant woman or likely to become pregnant or nursing and refusing to use an effective contraceptive method * Patient participating in another interventional clinical trial * Patient under guardianship or trusteeship