Old drug, new hope: spironolactone may help kids with rare Autism-Linked gene mutations
NCT ID NCT06678685
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether spironolactone, a common diuretic, can improve learning and behavior in children aged 3–10 with NCOR gene mutations, which are linked to autism spectrum disorder. Only 2 children will be enrolled, and researchers will measure changes in intelligence and autism symptoms. The drug is already used safely in children for other conditions, but this is an early exploratory trial.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
spironolactone
What this could lead to
If it works, this could point toward a treatment for learning and memory problems in children with certain NCOR gene mutations.
What could go wrong
This is a very small, early-stage trial with only 2 children, so results may not apply broadly. Spironolactone is generally safe but can affect potassium levels and blood pressure.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Qilu Hospital of Shandong University
RECRUITINGJinan, Shandong, 250012, China
Contact Phone: •••-•••-•••• Email: •••••@•••••