New drug cocktail shows promise for slowing kidney disease
NCT ID NCT05856760
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested whether adding sparsentan to a standard SGLT2 inhibitor can better protect kidneys in people with IgA nephropathy, a disease that can lead to kidney failure. 48 adults who were already on stable doses of both a blood pressure drug and an SGLT2 inhibitor took sparsentan for 28 weeks. Researchers measured changes in urine protein levels to see if kidney damage slowed down.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
sparsentan (also called Filspari) combined with an SGLT2 inhibitor (a type of diabetes drug that also protects kidneys)
What this could lead to
If it works, this combination could offer a new way to slow kidney damage and delay kidney failure in people with IgA nephropathy.
What could go wrong
This is a small, early-phase study with no placebo group, so results may not be definitive. The combination may not prove more effective than existing treatments.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Travere Investigation Site
Clifton Park, New York, 12065, United States
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Travere Investigational Site
Birmingham, Alabama, 35233, United States
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Travere Investigational Site
Chula Vista, California, 91910, United States
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Travere Investigational Site
Garden Grove, California, 92844, United States
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Travere Investigational Site
Glendale, California, 91206, United States
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Travere Investigational Site
Denver, Colorado, 80230, United States
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Travere Investigational Site
Boise, Idaho, 83706, United States
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Travere Investigational Site
Chubbuck, Idaho, 83202, United States
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Travere Investigational Site
Idaho Falls, Idaho, 83404, United States
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Travere Investigational Site
Chicago, Illinois, 60611, United States
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Travere Investigational Site
Evergreen Park, Illinois, 60805, United States
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Travere Investigational Site
Fort Wayne, Indiana, 46804, United States
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Travere Investigational Site
Kansas City, Kansas, 66160, United States
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Travere Investigational Site
Louisville, Kentucky, 40205, United States
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Travere Investigational Site
Shreveport, Louisiana, 71101, United States
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Travere Investigational Site
Albuquerque, New Mexico, 87109, United States
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Travere Investigational Site
Fresh Meadows, New York, 11365, United States
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Travere Investigational Site
New York, New York, 10013, United States
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Travere Investigational Site
Jacksonville, North Carolina, 28546, United States
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Travere Investigational Site
New Bern, North Carolina, 28562, United States
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Travere Investigational Site
Columbus, Ohio, 43210, United States
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Travere Investigational Site
Philadelphia, Pennsylvania, 19104, United States
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Travere Investigational Site
Columbia, South Carolina, 29203, United States
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Travere Investigational Site
Dallas, Texas, 75230, United States
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Travere Investigational Site
Dallas, Texas, 75246, United States
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Travere Investigational Site
Hong Kong, Hong Kong
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Travere Investigational Site
Kowloon, Hong Kong
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Travere Investigational Site
Shatin, Hong Kong
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Travere Investigational Site
Sheung Wan, Hong Kong
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Travere Investigational Site
Tsuen Wan, Hong Kong