Can a targeted pill offer hope for stubborn lung cancer?

NCT ID NCT04667234

NO_LONGER_AVAILABLE Disease control Sponsor: Amgen Source: ClinicalTrials.gov ↗

First seen Aug 20, 2026 · Last updated Aug 21, 2026 · Updated 1 time

Summary

This study provides expanded access to sotorasib, an oral drug designed to target a specific genetic mutation (KRAS G12C) found in some non-small cell lung cancers. It is for adults with advanced or metastatic disease who have already tried standard treatments, including chemotherapy, and cannot join other clinical trials. The goal is to give these patients a chance to receive the drug and to gather more information about its safety in a real-world setting.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: sotorasib (AMG 510), an oral tablet
What this could lead to: If it works, this could provide a treatment option for people with KRAS G12C-mutant lung cancer who have no other choices left.
What could go wrong: This is an expanded access program, not a controlled trial, so it may not prove effectiveness. Side effects are possible, and it is only for those who qualify.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LOCALLY ADVANCED METASTATIC NSCLC LOCALLY ADVANCED UNRESECTABLE NSCLC NON-SMALL CELL LUNG CANCER

Contacts and locations

Locations

Alaska Oncology and Hematology LLC

Anchorage, Alaska, 99508, United States
Arizona Oncology Associates Professional Corporation

Tucson, Arizona, 85711, United States
Baptist Cancer Center

Memphis, Tennessee, 38120, United States
Cancer Care Specialists of Central Illinois

Decatur, Illinois, 62526, United States
Cemic

Ciudad Autonoma de Buenos Aires, Buenos Aires, C1431FWO, Argentina
Chung Shan Medical University Hospital

Taichung, Taichung, 40201, Taiwan
Clearview Cancer Institute

Huntsville, Alabama, 35805, United States
Cleveland Clinic Taussig Cancer Institute

Cleveland, Ohio, 44195, United States
Clínica Universitaria Privada Reina Fabiola

Córdoba, Córdoba Province, X5004FHP, Argentina
Dana Farber Cancer Institute

Boston, Massachusetts, 02215, United States
Des Moines Oncology Research Association

Des Moines, Iowa, 50309, United States
Englewood Hospital and Medical Center

Englewood, New Jersey, 07631, United States
Erlanger East Hospital

Chattanooga, Tennessee, 37421, United States
Fox Chase Cancer Center

Philadelphia, Pennsylvania, 19111, United States
Fundacao Pio 12 Hospital de Cancer de Barretos

Barretos, São Paulo, 14784-400, Brazil
Hospital Aleman

Ciudad Autonoma de Buenos Aires, Buenos Aires, C1118AAT, Argentina
Hospital Sirio Libanes

Brasília, Federal District, 70200-730, Brazil
Instituto Médico Especializado Alexander Fleming

Capital Federal, Buenos Aires, C1426ANZ, Argentina
Instituto de Oncologia do Parana

Curitiba, Paraná, 80040-170, Brazil
Ironwood Cancer and Research Center

Chandler, Arizona, 85224, United States
Kaiser Permanente

Lone Tree, Colorado, 80124, United States
Kaohsiung Chang Gung Memorial Hospital

Kaohsiung City, Kaohsiung, 83301, Taiwan
King Abdulaziz Medical City - National Guard Hospital

Riyadh, 11426, Saudi Arabia
King Fahad Specialist Hospital

Dammam, 32253, Saudi Arabia
King Faisal Specialist Hospital

Riyadh, 12713, Saudi Arabia
King Saud University Medical City-King Khalid University Hospital

Riyadh, 12372, Saudi Arabia
LeHigh Valley Hospital

Allentown, Pennsylvania, 18103, United States
Liga Norte-Riograndense Contra O Cancer

Natal, Rio Grande do Norte, 59075-740, Brazil
Linkou Chang Gung Memorial Hospital

Taoyuan, Taoyuan, 33305, Taiwan
Louisiana Hematology Oncology Associates

Baton Rouge, Louisiana, 70809, United States
Maryland Oncology Hematology, PA

Rockville, Maryland, 20850, United States
McFarland Clinic PC

Ames, Iowa, 50010, United States
Meir Medical Center

Kfar Saba, 4428164, Israel
Mid Michigan Medical Center

Midland, Michigan, 48640, United States
National Cheng Kung University Hospital

Tainan, Tainan, 70403, Taiwan
National Taiwan University Hospital

Taipei, Taipei, 10002, Taiwan
Nebraska Cancer Specialists

Omaha, Nebraska, 68130, United States
Northern Light Cancer Center

Brewer, Maine, 04412, United States
Oncoclinicas Rio de Janeiro S A

Rio de Janeiro/RJ, 22250-905, Brazil
Oncology Hematology Associates

Springfield, Missouri, 65807, United States
Overlook Medical Center

Summit, New Jersey, 91010, United States
Personal Oncologia de Precisao e Personalizada

Belo Horizonte, Minas Gerais, 30130-090, Brazil
Rabin Medical Center

Petah Tikva, 4941492, Israel
Sacred Heart Medical Oncology Group

Pensacola, Florida, 32504, United States
Saint Joseph East

Lexington, Kentucky, 40509, United States
Saint Lukes Cancer Institute

Kansas City, Missouri, 64111, United States
Saint Marys Medical Center

Huntington, West Virginia, 25705, United States
San Luis Valley Health Regional Medical Center

Alamosa, Colorado, 81101, United States
Scranton Hematology Oncology

Scranton, Pennsylvania, 18510, United States
Shaare Zedek Medical Center

Petah Tikva, 4941492, Israel
Taipei Veterans General Hospital

Taipei, Taipei, 11217, Taiwan
University of Pittsburgh Medical Center Western Maryland

Cumberland, Maryland, 21502, United States
Veterans General Hospital - Taichung

Taichung, Taichung, 40705, Taiwan
Wake Forest Baptist Comprehensive Cancer Research Center

Winston-Salem, North Carolina, 27157, United States
YNOVA Pesquisa Clinica

Florianópolis, Santa Catarina, 88034-000, Brazil

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