Can a wakefulness drug help Early-Morning workers stay alert?

NCT ID NCT04788953

Terminated Symptom relief Sponsor: Charles A. Czeisler, PhD, MD Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study tested whether the drug solriamfetol (Sunosi) can reduce excessive sleepiness in people who start work between 3 and 6 AM. The trial planned to enroll 84 participants but was terminated early. Researchers measured sleepiness using a test that tracks how long people can stay awake, along with self-reported sleepiness scores.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Solriamfetol (Sunosi) oral tablet
What this could lead to: If successful, this could provide a treatment option for excessive sleepiness in people who work very early morning shifts.
What could go wrong: The trial was terminated early with only 84 participants, so results are limited. Solriamfetol may cause side effects like headache or nausea, and its long-term safety in shift workers is not fully known.

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Conditions

The condition(s) this trial relates to.

circadian rhythm sleep disorder, shift work type Disorders of Excessive Somnolence hypersomnia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

EXCESSIVE SLEEPINESS SHIFT WORK DISORDER

Contacts and locations

Locations

Brigham and Women's Hospital

Boston, Massachusetts, 02115, United States

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