Can a wakefulness drug help Early-Morning workers stay alert?
NCT ID NCT04788953
First seen Jun 25, 2026 · Last updated Jun 26, 2026 · Updated 1 time
Summary
This study tested whether the drug solriamfetol (Sunosi) can reduce excessive sleepiness in people who start work between 3 and 6 AM. The trial planned to enroll 84 participants but was terminated early. Researchers measured sleepiness using a test that tracks how long people can stay awake, along with self-reported sleepiness scores.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Solriamfetol (Sunosi) oral tablet
What this could lead to
If successful, this could provide a treatment option for excessive sleepiness in people who work very early morning shifts.
What could go wrong
The trial was terminated early with only 84 participants, so results are limited. Solriamfetol may cause side effects like headache or nausea, and its long-term safety in shift workers is not fully known.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Brigham and Women's Hospital
Boston, Massachusetts, 02115, United States