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Can baking soda save kidneys in the ICU? new trial aims to find out

NCT ID NCT05697770

Ongoing Disease control Sponsor: Australian and New Zealand Intensive Care Research Centre Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether giving sodium bicarbonate (baking soda) to adults in the intensive care unit with metabolic acidosis can reduce the risk of major kidney problems or death within 30 days. The trial involves 500 participants who will receive either sodium bicarbonate or a placebo (sugar water) through an IV for up to 5 hours. Researchers will track outcomes like death, need for dialysis, and persistent kidney damage.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
sodium bicarbonate
What this could lead to
If it works, this could provide a simple, low-cost treatment to prevent kidney failure or death in critically ill patients with metabolic acidosis.
What could go wrong
This is a phase 3 trial, but previous studies on sodium bicarbonate for acidosis have shown mixed results. The benefit may be small or absent, and the infusion itself carries risks like fluid overload.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Acidosis metabolic acidosis Shock

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

METABOLIC ACIDOSIS SHOCK

Contacts and locations

Locations

  • Auckland City Hospital (CVICU)

    Auckland, Auckland, 1023, New Zealand

  • Auckland City Hospital (DCCM)

    Auckland, Auckland, 1023, New Zealand

  • Bendigo Hospital

    Bendigo, Victoria, 3550, Australia

  • Bunbury Regional Hospital

    Bunbury, Western Australia, 6230, Australia

  • Cairns Hospital

    Cairns, Queensland, 4870, Australia

  • Calvary Mater Newcastle

    Waratah, New South Wales, 2298, Australia

  • Canberra Hospital

    Garran, Australian Capital Territory, 2605, Australia

  • Casey Hospital

    Berwick, Victoria, 3806, Australia

  • Centro de Estudos e de Pesquisas em Terapia Intensiva

    Curitiba, Paraná, 82530-200, Brazil

  • Christchurch Hospital

    Christchurch, Christchurch, 4710, New Zealand

  • Dandenong Hospital

    Dandenong, Victoria, 3175, Australia

  • Deep Hospital

    Ludhiana, Punjab, 141002, India

  • Dunedin Hospital

    Dunedin, Dunedin, 9016, New Zealand

  • Epworth

    Richmond, Victoria, 3121, Australia

  • Flinders Medical Centre

    Bedford Park, South Australia, Australia

  • Footscray Hospital

    Footscray, Victoria, 3011, Australia

  • Frankston Hospital

    Frankston, Victoria, 3199, Australia

  • Gold Coast University Hospital

    Southport, Queensland, 4215, Australia

  • Gosford Hospital

    Gosford, New South Wales, 2250, Australia

  • Grapmians Health

    Ballarat, Victoria, 3350, Australia

  • Ipswich Hospital

    Ipswich, Queensland, 4305, Australia

  • Jawaharlal Institute of Postgraduate Medical Education and Research

    Puducherry, Puducherry, 605006, India

  • King Abdullah International Medical Research Center

    Riyadh, Riyadh Region, 11481, Saudi Arabia

  • Lyell McEwin Hospital

    Elizabeth Vale, South Australia, 5112, Australia

  • Mater Hospital

    South Brisbane, Queensland, 4101, Australia

  • Middlemore Hospital

    Auckland, Auckland, 2025, New Zealand

  • Monash Medical Centre

    Clayton, Victoria, 3168, Australia

  • Nepean Hospital

    Kingswood, New South Wales, 2747, Australia

  • Orange Health Service

    Orange, New South Wales, 2800, Australia

  • Peninsula Private Hospital

    Langwarrin, Victoria, 3910, Australia

  • Princess Alexandra Hopsital

    Woolloongabba, Queensland, 4102, Australia

  • Queen Elizabeth II Jubilee Hospital

    Coopers Plains, Queensland, 4108, Australia

  • Rotorua Hospital

    Rotorua, Rotorua, 3010, New Zealand

  • Royal Adelaide Hospital

    Adelaide, South Australia, 5000, Australia

  • Royal Brisbane and Women's Hospital

    Herston, Queensland, 4006, Australia

  • Royal Darwin Hospital

    Tiwi, Northern Territory, 0810, Australia

  • Royal North Shore Hospital

    Saint Leonards, New South Wales, 2065, Australia

  • Royal Perth Hospital

    Perth, Western Australia, 6000, Australia

  • Royal Prince Alfred Hospital

    Camperdown, New South Wales, 2050, Australia

  • St Vincent's Hospital Sydney

    Darlinghurst, New South Wales, 2010, Australia

  • St. Vincent's Hospital Melbourne

    Fitzroy, Victoria, 3065, Australia

  • Sultan Qaboos Comprehensive Cancer Care and Research Center

    Seeb, Oman

  • Sunshine Coast University Hospital

    Birtinya, Queensland, 4575, Australia

  • Sunshine Hospital

    St Albans, Victoria, 3021, Australia

  • Sutherland Hospital

    Caringbah, New South Wales, 2229, Australia

  • Sydney Adventist Hospital

    Wahroonga, New South Wales, 2076, Australia

  • The Alfred Hospital

    Melbourne, Victoria, 3004, Australia

  • The Austin Hospital

    Heidelberg, Victoria, 3084, Australia

  • The Jikei University Hospital

    Minato, Tokyo, 105-0003, Japan

  • The Queen Elizabeth Hospital

    Woodville, South Australia, 5011, Australia

  • The Victorian Heart Hospital

    Clayton, Victoria, 3065, Australia

  • Townsville University Hospital

    Douglas, Queensland, 4814, Australia

  • University Hospital Geelong

    Geelong, Victoria, 3220, Australia

  • Waikato Hospital

    Hamilton, Hamilton, 3204, New Zealand

  • Wellington Regional Hospital

    Wellington, New Zealand

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