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Can smoking sabotage gum grafts? a new trial investigates

NCT ID NCT07777185

Knowledge-focused Sponsor: Ankara University Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 20, 2026 · Last updated Aug 26, 2026 · Updated 3 times

Summary

This study looks at whether smoking changes the tissue in the roof of the mouth where a gum graft is taken, and whether that affects how well the graft covers exposed tooth roots. It will compare 12 smokers with 12 non-smokers, all receiving the same surgical procedure for gum recession. Using ultrasound and tissue analysis, researchers will measure healing and success over three months. The goal is to understand if smoking impairs graft outcomes, which could guide future treatment decisions.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Coronally advanced flap with subepithelial connective tissue graft (CAF + CTG), a surgical procedure to cover exposed tooth roots
What this could lead to
If smoking is shown to impair graft healing, this could lead to tailored treatment plans and better outcomes for smokers undergoing gum recession surgery.
What could go wrong
This is a small, early-stage study with only 24 participants, so results may not apply broadly. Smoking's effects on healing are complex, and the study may not capture all factors.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 24 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Aug 2026

An estimate. Start dates often move.

Expected to finish

Feb 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Aged 18 years or older. 2. Systemically healthy, with no systemic disease that could directly affect status or wound healing. 3. Presence of an isolated facial recession on non-molar maxillary teeth: greater than 2 mm, less than 5 mm (up to a maximum of 5 mm). 4. Recession classified as Cairo Type 1 (RT1 = Miller Class I and II), meaning gingival recession without interproximal attachment loss. 5. No previous soft tissue surgery at the surgical site. 6. Good oral hygiene (full-mouth bleeding on probing below 10%). 7. No soft tissue graft previously harvested from the palatal donor site. 8. Able to comply with all study-related procedures, including attendance at all follow-up visits. Exclusion Criteria: 1. Untreated periodontitis or peri-implantitis. 2. Any systemic disease that could potentially impair wound healing, such as diabetes or connective tissue disorders. 3. Pregnancy or breastfeeding. 4. Previous or concurrent use of medications affecting mucosal healing (e.g., steroids or high-dose anti-inflammatory drugs). 5. Coagulation or bleeding disorders. 6. Cleft palate. 7. Active orthodontic treatment with fixed or removable appliances. 8. A history of malignancy, radiotherapy, or chemotherapy for malignancy within the past 5 years. 9. Antibiotic therapy within the past 6 months. 10. Previous connective tissue graft harvested from the palatal donor site. 11. Any other surgical procedure at the palatal donor or recipient site (e.g., apical resection or crown lengthening).

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Conditions

The condition(s) this trial relates to.

gingival recession

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Gingival recession localized moderate Palatal morphology Soft tissue augmentation

How to take part

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  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

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Contacts and locations

Locations

  • Ankara University Faculty of Dentistry

    Ankara, Yenimahalle, 06560, Turkey (Türkiye)

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