Inflammation's hidden role in depression: new study targets reward pathways

NCT ID NCT03848715

First seen Feb 01, 2026 · Last updated May 22, 2026 · Updated 15 times

Summary

This completed study looked at how inflammation might change the way younger women (ages 25-44) experience reward, such as money or smiling faces, and how that relates to depression. Researchers gave 40 healthy women a mild inflammatory substance or a placebo and measured their responses to rewards using computer tasks and questionnaires. The goal was to better understand the link between inflammation and depression, not to test a treatment.

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Contacts and locations

Locations

  • Norman Cousins Center for Psychoneuroimmunology, University of California, Los Angeles

    Los Angeles, California, 90095, United States

Conditions

Explore the condition pages connected to this study.