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Three nights off CPAP: a window into sleep Apnea's metabolic toll

NCT ID NCT02824263

Knowledge-focused Sponsor: Johns Hopkins University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 24, 2026 · Last updated Sep 25, 2026 · Updated 1 time

Summary

Obstructive sleep apnea is linked to diabetes and heart disease, but researchers do not know exactly how. This study enrolls people with moderate to severe sleep apnea who normally use CPAP. Participants spend nights in a sleep lab either using CPAP or after stopping it for three nights, while researchers draw blood to compare levels of glucose, insulin, triglycerides, and free fatty acids during sleep.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
CPAP withdrawal (stopping continuous positive airway pressure therapy for three nights)
What this could lead to
If sleep apnea changes metabolism during sleep, this could help explain why the condition raises the risk of diabetes and heart disease, and point to better ways to lower that risk.
What could go wrong
This is a small, short-term study of blood markers during sleep, not a test of whether treating apnea prevents diabetes. Three nights off CPAP may not reflect long-term effects, and the findings may not apply to everyone with sleep apnea.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

144 people

The number who actually took part.

Started

Jul 2016

Finished

Dec 2022

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

20 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * History of moderate to severe Obstructive sleep apnea (OSA) (AHI or respiratory disturbance index (RDI)\> 10). * They must also own a CPAP machine and report the ability to tolerate sleeping with or without CPAP during the night. Exclusion Criteria: * Uncontrolled hypertension with systolic blood pressure \>170 or diastolic blood pressure \> 110 * Congestive heart failure * Use of clonidine or nicotinic acid medication * Diabetes requiring the use of insulin * Known pregnancy, by urine testing in women of child-bearing age * History of falling asleep while driving, near miss * High risk occupation (pilot, commercial driver) * Hemoglobin \< 10 g/dL on point of care screening

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Conditions

The condition(s) this trial relates to.

obstructive sleep apnea syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Obstructive sleep apnea

Contacts and locations

Locations

  • Johns Hopkins Bayview Medical Center

    Baltimore, Maryland, 21224, United States

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