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Silver and sound: can ultrasound push nanoparticles into diabetic wounds?

NCT ID NCT07821996

Symptom relief Sponsor: Cairo University Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
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Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 16, 2026 · Last updated Sep 17, 2026 · Updated 1 time

Summary

Researchers at Cairo University are testing whether a silver nanoparticle gel, pushed into diabetic foot ulcers with low-intensity ultrasound, helps these chronic wounds heal faster. The trial enrolls 36 adults with type 1 or type 2 diabetes who have a foot ulcer and a superficial infection. Participants receive either the silver nanoparticle phonophoresis, standard ultrasound with a plain gel followed by topical silver gel, or standard wound care. The team measures changes in ulcer surface area and volume over three weeks of treatment.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
silver nanoparticle gel delivered with low-intensity ultrasound (phonophoresis)
What this could lead to
If it works, this could offer a non-invasive way to speed healing of chronic diabetic foot ulcers and reduce the risk of infection or amputation.
What could go wrong
This is a small, early study of 36 people, so results may not hold in larger groups. Ultrasound and silver gels can irritate skin, and healing depends on many factors beyond the treatment itself.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

36 people

The number who actually took part.

Started

Apr 2025

Finished

Apr 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

30 to 60 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Type1 or Type 2 Diabetes Mellitus with chronic foot ulcer. * Clear clinical documentation of superficial infection. Exclusion Criteria: * Deep bone osteomyelitis. * Peripheral gangrene. * Severe local ischemia. * Pregnancy. * Systemic multi-organ failure.

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Conditions

The condition(s) this trial relates to.

Diabetic Foot

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Diabetic foot ulcer

Contacts and locations

Locations

  • Cairo university

    Cairo, Egypt

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