New eye drop shows promise for dry eye sufferers in Late-Stage trial

NCT ID NCT05411367

Completed Symptom relief Sponsor: Seikagaku Corporation Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This Phase 3 trial tested SI-614 eye drops, a modified form of sodium hyaluronate, against placebo in 232 adults with dry eye disease. Participants used the drops four times daily for 84 days. The study measured changes in eye surface staining (a sign of damage) and daily symptom scores. The goal is to see if SI-614 can safely reduce eye discomfort and improve eye surface health better than placebo.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: SI-614 (a chemically modified form of sodium hyaluronate) eye drops
What this could lead to: If successful, SI-614 could offer a new treatment option to reduce eye surface damage and ease discomfort in people with dry eye disease.
What could go wrong: This is a completed Phase 3 trial, but results are not yet published. The improvement over placebo may be small, and not everyone may benefit. Dry eye is complex and symptoms vary widely.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

dry eye syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DRY EYE DISEASE

Contacts and locations

Locations

Andover Eye Associates, Inc.

Andover, Massachusetts, 01810, United States
Butchertown Clinical Trials

Louisville, Kentucky, 40206, United States
CORE Inc, Vita Eye Clinic

Shelby, North Carolina, 28150, United States
Center for Sight

Henderson, Nevada, 89052, United States
Eye Research Foundation

Newport Beach, California, 92663, United States
Total Eye Care, PA

Memphis, Tennessee, 38119, United States

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