Shingles shot put to the test in older HIV patients

NCT ID NCT05575830

Ongoing Disease control Sponsor: Calmy Alexandra Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study looks at how well the Shingrix vaccine protects against shingles in people over 50 living with HIV, compared to healthy adults of the same age and gender. About 225 participants will receive two doses of the vaccine and be monitored for one year. The goal is to see if the vaccine triggers a strong immune response and is safe in this group.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Shingrix (recombinant zoster vaccine)
What this could lead to: If successful, this could show that the Shingrix vaccine works well in older adults with HIV, helping prevent shingles in this group.
What could go wrong: This is a phase 4 study, so the vaccine is already approved. The main question is whether it works as well in people with HIV, but immune responses may be weaker, and side effects like injection-site reactions are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

HIV infectious disease herpes zoster prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

RZV VACCINE (SHINGRIX ®)

Contacts and locations

Locations

Bern University Hospital (Inselspital)

Bern, Canton of Bern, 3010, Switzerland
CHU de Bordeaux - Hôpital Haut-Lévèque

Pessac, Gironde, 33604, France
Centre Hospitalier Universitaire Vaudoise (CHUV)

Lausanne, Canton of Vaud, 1011, Switzerland
Ente Ospedaliero Cantonale

Lugano, Canton Ticino, 6900, Switzerland
Hôpital Saint-André, CHU de Bordeaux

Bordeaux, Bordeaux, 33075, France
Kantonsspital

Sankt Gallen, Canton of St. Gallen, 9007, Switzerland
SMIT - Service de Maladies Infectieuses et Tropicales Le Tripode -Groupe Hospitalier Pellegrin

Bordeaux, France, 33000, France
University Hospital Basel

Basel, Basel, 4031, Switzerland
University Hospital Zurich

Zurich, Canton of Zurich, 8091, Switzerland
University Hospitals of Geneva

Geneva, Canton of Geneva, 1205, Switzerland

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