Could a diabetes drug make heart inflammation easier to spot?
NCT ID NCT06510894
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether a drug called sotagliflozin, combined with a short ketogenic diet, can help suppress normal sugar use by the heart. This would make PET scans clearer for detecting inflammation caused by cardiac sarcoidosis. Forty healthy volunteers will take the drug for a week and follow a special diet for 1 or 3 days before a scan. The goal is to see if this approach improves image quality, not to treat any disease.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Sotagliflozin (a drug that blocks sugar absorption to help the heart use less glucose)
What this could lead to
If successful, this could lead to a better, more reliable way to detect heart inflammation using PET scans, improving diagnosis of cardiac sarcoidosis.
What could go wrong
This is a very early pilot study in only 40 healthy people, not patients. It tests imaging, not treatment, so it may not translate to real-world diagnostic improvements.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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University of Pennsylvania
RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
Contact Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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