New combo therapy aims to eliminate rectal tumors without surgery
NCT ID NCT07150949
First seen Nov 01, 2025 · Last updated Apr 28, 2026 · Updated 22 times
Summary
This study tests two different treatment plans for people with locally advanced rectal cancer that hasn't spread. One group gets standard long-course chemoradiation followed by chemo. The other gets short-course radiation followed by chemo, an immunotherapy drug (PD-1 antibody), and an anti-inflammatory drug (COX-2 inhibitor). The goal is to see which approach leads to a complete disappearance of the cancer, possibly avoiding the need for surgery. The trial involves 138 adults with a specific type of rectal cancer (MSS/pMMR).
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Fudan University Shanghai Cancer Center
RECRUITINGShanghai, Shanghai Municipality, 200030, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
Conditions
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