New combo therapy for tough bladder cancer cases shows early promise

NCT ID NCT04856189

First seen Jun 27, 2026 ยท Last updated Jun 27, 2026

Summary

This study tested a combination of two drugs, selinexor and pembrolizumab, in people with advanced bladder cancer who either couldn't take the standard chemo drug cisplatin or whose cancer got worse after cisplatin. The goal was to find the best dose and see if the combo could shrink tumors. Only 4 people took part before the study was stopped early, so results are very limited.

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Conditions

The condition(s) this trial relates to.

bladder transitional cell carcinoma transitional cell carcinoma urothelial carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • University of California Davis Comprehensive Cancer Center

    Sacramento, California, 95817, United States