Radiation plus two cancer drugs tested in advanced liver cancer trial
NCT ID NCT05488522
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-phase study tests whether adding precise radiation (SBRT) to a standard two-drug combination (atezolizumab and bevacizumab) is safe and tolerable for people with advanced liver cancer that cannot be treated with surgery. The trial enrolls 18 participants and will also look at how well the tumors respond. The goal is to find a dose and schedule for future larger studies.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Stereotactic body radiotherapy (SBRT) plus atezolizumab and bevacizumab
- What this could lead to
- If successful, this could point toward a new combination treatment that helps control advanced liver cancer when standard therapies are no longer effective.
- What could go wrong
- This is a very early (phase I) trial with only 18 participants, focused on safety and dosing. It is not designed to prove the combination works, and side effects from radiation or the drugs could be serious.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Abramson Cancer Center of the University of Pennsylvania
RECRUITINGPhiladelphia, Pennsylvania, 19104-4283, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Could a simple scan and blood test outsmart liver cancer?
- Could a vaccine help fight Hard-to-Treat cancers?
- Could a tailored diet before surgery boost liver cancer recovery?
- Can a new PET tracer light up hidden cancers?
- A new test could reveal how radiation affects the liver
- Can an immunotherapy drug keep liver cancer at bay after surgery?